Research output per year
Research output per year
Publications
- 1 - 50 out of 122 results
Search results
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2024
Body‐wide genetic deficiency of poly(ADP‐ribose) polymerase 14 sensitizes mice to colitis
Vedantham, M., Polari, L., Poosakkannu, A., Pinto, R. G., Sakari, M., Laine, J., Sipilä, P., Määttä, J., Gerke, H., Rissanen, T., Rantakari, P., Toivola, D. M. & Pulliainen, A. T., 15 Jul 2024, In: FASEB Journal. 38, 13, 23 p., e23775.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Downloads (Pure) -
Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism
Nyström, J. H., Heikkilä, T. R. H., Thapa, K., Pulli, I., Törnquist, K. & Toivola, D. M., 1 Sept 2024, In: AJP - Gastrointestinal and Liver Physiology. 327, 3, p. G438-G453Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)3 Downloads (Pure) -
Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation
Ilomäki, M., Polari, L., Stenvall, C.-G. A., Tayyab, M., Kähärä, K., Ridge, K. M. & Toivola, D. M., 1 Jan 2024, In: AJP - Gastrointestinal and Liver Physiology. 326, 1, p. G67-G77 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)151 Downloads (Pure) -
Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice
Hjelt, A., Anttila, S., Wiklund, A., Rokka, A., Al‐Ramahi, D., Toivola, D. M., Polari, L. & Määttä, J., Aug 2024, In: Pharmacology Research & Perspectives. 12, 4, 16 p., e1234.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)9 Downloads (Pure) -
Improved breast milk proteome coverage by DIA based LC-MS/MS method
Viitaharju, J., Polari, L., Kauko, O., Merilahti, J., Rokka, A., Toivola, D. M. & Laitinen, K., Jul 2024, In: Proteomics. 24, 14, 2300340.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)14 Downloads (Pure) -
The keratin-desmosome scaffold of internal epithelia in health and disease - The plot is thickening
Toivola, D. M., Polari, L., Schwerd, T., Schlegel, N. & Strnad, P., Feb 2024, In: Current Opinion in Cell Biology. 86, 8 p., 102282.Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open AccessFile3 Citations (Scopus)78 Downloads (Pure) -
β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting
Baghestani, S., Haldin, C., Kosijer, P., Alam, C. M. & Toivola, D. M., 24 Aug 2024, In: American Journal of Physiology - Cell Physiology. 327, 2, p. C462-C476 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
2023
Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease
Bhowmik, A. A., Heikkilä, T. R. H., Polari, L., Virta, J., Liljenbäck, H., Moisio, O., Li, X.-G., Viitanen, R., Jalkanen, S., Koffert, J., Toivola, D. M. & Roivainen, A., 18 Dec 2023, (E-pub ahead of print) In: Molecular Imaging and Biology. 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile15 Downloads (Pure) -
Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3-year follow-up study
Tenhami, M., Polari, L., Kujari, H., Löyttyniemi, E., Toivola, D. & Voutilainen, M., 24 Jul 2023, In: Scientific Reports. 13, 1, 9 p., 11979.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure) -
Regulation of epithelial transitional states in murine and human pulmonary fibrosis
Wang, F., Ting, C., Riemondy, K. A., Douglas, M., Foster, K., Patel, N., Kaku, N., Linsalata, A., Nemzek, J., Varisco, B. M., Cohen, E., Wilson, J. A., Riches, D. W., Redente, E. F., Toivola, D. M., Zhou, X., Moore, B. B., Coulombe, P. A., Omary, M. B. & Zemans, R. L., 15 Nov 2023, In: Journal of Clinical Investigation. 133, 22, 18 p., e165612.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile47 Citations (Scopus)14 Downloads (Pure) -
Supporting Microscopy Learning with Ocul-AR, a Virtual and Augmented Reality-Powered Mobile Application
Pylvänäinen, J., Solis, J., Toivola, D. & Kankaanpää, P., 15 May 2023, In: CEUR Workshop Proceedings. 3393, p. 28-37 10 p.Research output: Contribution to journal › Conference article › Scientific › peer-review
Open Access -
The Effect of a Fish Oil and/or Probiotic Intervention from Early Pregnancy Onwards on Colostrum Immune Mediators: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial in Overweight/Obese Mothers
Jenni, S., Lauri, P., Marko, K., Lotta, S., Laajala, T. D., Tero, V., Toivola, D. M. & Kirsi, L., Aug 2023, In: Molecular Nutrition and Food Research. 67, 15, 12 p., 2200446.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)66 Downloads (Pure) -
2022
Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance
Polari, L., Tenhami, M., Anttila, S., Helenius, T., Kujari, H., Kallajoki, M., Voutilainen, M. & Toivola, D. M., 23 Dec 2022, In: Scientific Reports. 12, 1, 10 p., 22213.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Citations (Scopus)27 Downloads (Pure) -
Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells
Stenvall, C.-G. A., Nyström, J. H., Butler-Hallissey, C., Jansson, T., Heikkilä, T. R. H., Adam, S. A., Foisner, R., Goldman, R. D., Ridge, K. M. & Toivola, D. M., Nov 2022, In: Molecular biology of the cell. 33, 13, 14 p., ar121.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile11 Citations (Scopus)137 Downloads (Pure) -
Keratiinit suoliston epiteelisoluissa ja paksusuolensyövän analytiikassa
Polari, L., Voutilainen, M., Kallajoki, M. & Toivola, D., Jan 2022, In: Duodecim: lääketieteellinen aikakauskirja. 138, 10, p. 889 896 p., 138.Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open AccessFile10 Downloads (Pure) -
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
Stenvall, C.-G. A., Tayyab, M., Grönroos, T. J., Ilomäki, M. A., Viiri, K., Ridge, K. M., Polari, L. & Toivola, D. M., Jan 2022, In: Cellular and Molecular Life Sciences. 79, 1, 17 p., 10.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile15 Citations (Scopus)47 Downloads (Pure) -
Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine
Wang, L., Mohanasundaram, P., Lindström, M., Asghar, M. N., Sultana, G., Misiorek, J. O., Jiu, Y., Chen, H., Chen, Z., Toivola, D. M., Cheng, F. & Eriksson, J. E., 25 Mar 2022, In: Frontiers in Cell and Developmental Biology. 10, 13 p., 862237.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile9 Citations (Scopus)45 Downloads (Pure) -
2021
Biokuvantamisen uusi sukupolvi
Translated title of the contribution :The new generation of bioimaging Research output: Contribution to journal › Article › Scientific
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Intermediate filament keratins in the exocrine pancreas
Alam, C., Baghestani, S. & Toivola, D., Dec 2021, The Pancreas: Biology and Physiology. Gorelick, F. & Williams, J. (eds.). Michigan Publishing, p. 72-84 12 p.Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review
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Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes
Alam, C. M., Baghestani, S., Pajari, A., Omary, M. B. & Toivola, D. M., 21 Jul 2021, In: International Journal of Molecular Sciences. 22, 15, p. 1-16 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access8 Citations (Scopus) -
2020
Intermediate Filament Keratins in The Exocrine Pancreas
Alam, C. M., Baghestani, S. & Toivola, D., 2020, In: Pancreapedia.Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open Access -
Keratin intermediate filaments in the colon: guardians of epithelial homeostasis
Polari, L., Alam, C. M., Nyström, J. H., Heikkilä, T., Tayyab, M., Baghestani, S. & Toivola, D. M., 2020, In: International Journal of Biochemistry and Cell Biology. 129, 105878.Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open AccessFile45 Citations (Scopus)42 Downloads (Pure) -
2019
Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis
Polari, L., Anttila, S., Helenius, T., Wiklund, A., Linnanen, T., Toivola, D. & Määttä, J., 2019, In: International Journal of Molecular Sciences. 20, 12, p. –Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile10 Citations (Scopus)84 Downloads (Pure) -
Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells
Pulli, I., Löf, C., Blom, T., Asghar, M. Y., Lassila, T., Bäck, N., Lin, K.-L., Nyström, J., Kemppainen, K., Toivola, D., Dufour, E., Sanz, A., Cooper, H., Parys, J. & Törnquist, K., 2019, In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866, 9, p. 1475–1486 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
8 Citations (Scopus) -
2018
Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes
Alam, C., Silvander, J., Helenius, T. & Toivola, D., 2018, In: Acta Physiologica. 224, 2, p. –Research output: Contribution to journal › Article › Scientific › peer-review
3 Citations (Scopus) -
Undrans Mosaik. Cantata celebrating Åbo Akademi 100 years. First Performance, Vaasa Church. Florakören, Brahe Djäknar, Pedavoces, Soloists 17.3.2018
Tuori, S., Kivinen, N. H., Toivola, D., Långbacka, U., Siegel, D. & Back, S.-O., 2018Research output: Non-textual form › Composition › Solo art production
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2017
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway
Lähdeniemi, I., Misiorek, J., Antila, C., Landor, S., Stenvall, C.-G., Fortelius, L., Bergström, L., Sahlgren, C. & Toivola, D., 2017, In: Cell Death and Differentiation. 24, 6, p. 984–996Research output: Contribution to journal › Article › Scientific › peer-review
43 Citations (Scopus) -
Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis
Silvander, J., Kvarnström, S., Kumari-Ilieva, A., Shrestha, A., Alam, C. & Toivola, D., 2017, In: FASEB Journal. 31, 10, p. 4578–4587Research output: Contribution to journal › Article › Scientific › peer-review
14 Citations (Scopus) -
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems
Sahlgren, C., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T., Toivola, D., Abankwa, D., Rosling, A., Sen Karaman, D., Salo-Ahen, O., Österbacka, R., Eriksson, J., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M. S. & Rosenholm, J. & 1 others, , 2017, In: Advanced Healthcare Materials. p. 1–34Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open AccessFile39 Citations (Scopus)50 Downloads (Pure) -
2016
Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway
Misiorek, J., Lähdeniemi, I., Nyström, J., Paramonov, V. M., Gullmets, J., Saarento, H., Rivero Müller, A., Husøy, T., Lähdeniemi, I. & Toivola, D., 2016, In: Carcinogenesis. 37, 8, p. 777–786Research output: Contribution to journal › Article › Scientific › peer-review
32 Citations (Scopus) -
Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon
Asghar, M. N., Priyamvada, S., Nyström, J., Natarajan Anbazhagan, A., Dudeja, P. K. & Toivola, D., 2016, In: AJP - Gastrointestinal and Liver Physiology. 310, 11, p. G1147–G1154Research output: Contribution to journal › Article › Scientific › peer-review
15 Citations (Scopus) -
Keratins are altered in intestinal disease-related stress responses
Helenius, T., Antman, C., Asghar, M. N., Nyström, J. & Toivola, D., 2016, In: Cells. 5, 35, p. 1–19Research output: Contribution to journal › Article › Scientific › peer-review
19 Citations (Scopus) -
Simple Epithelial Keratins
Strnad, P., Guldiken, N., Helenius, T., Misiorek, J., Nyström, J., Lähdeniemi, I., Silvander, J., Kuscuoglu, D. & Toivola, D., 2016, In: Methods in Enzymology. 568, p. 351–388Research output: Contribution to journal › Review Article or Literature Review › peer-review
5 Citations (Scopus) -
Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles
Desai, D., Prabhakar, N., Mamaeva, V., Sen Karaman, D., Lähdeniemi, I., Sahlgren, C., Rosenholm, J. & Toivola, D., 2016, In: International Journal of Nanomedicine. 11, p. 299–313Research output: Contribution to journal › Article › Scientific › peer-review
44 Citations (Scopus) -
2015
Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice
Toivola, D., HABTEZION, A., Misiorek, J., [Unknown], Z. L. X., Nyström, J., SHARPE, O., [Unknown], R. W. H., KWAN, R. & [Unknown], O. M. B., 2015, In: FASEB Journal. 29, 12, p. 5081–5089Research output: Contribution to journal › Article › Scientific › peer-review
12 Citations (Scopus) -
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism
Helenius, T., Misiorek, J., Nyström, J., Fortelius, L., HABTEZION, A., LIAO, J., Asghar, M. N., ZHANG, H., AZHAR, S., [Unknown], O. M. B. & Toivola, D., 2015, In: Molecular biology of the cell. 26, 12, p. 2298–2310Research output: Contribution to journal › Article › Scientific › peer-review
40 Citations (Scopus) -
Keratins in health and disease
Toivola, D., BOOR, P., Alam, C. & STRNAD, P., 2015, In: Current Opinion in Cell Biology. 32, p. 73–81Research output: Contribution to journal › Review Article or Literature Review › peer-review
182 Citations (Scopus) -
The amount of keratins matters for stress protection of the colonic epithelium
Asghar, M. N., Silvander, J., Helenius, T., Lähdeniemi, I., Alam, C., Fortelius, L., [Unknown], H. R. O. & Toivola, D., 2015, In: PLoS ONE. 10, 5, p. 1–17Research output: Contribution to journal › Article › Scientific › peer-review
27 Citations (Scopus) -
2014
Design considerations for mesoporous silica nanoparticulate systems in facilitating biomedical applications
Desai, D., Sen Karaman, D., Prabhakar, N., Tadayon, S., Duchanoy, A., Toivola, D., Rajput, S., Näreoja, T. & Rosenholm, J., 2014, In: Mesoporous Biomaterials. 1, 1, p. 16–43Research output: Contribution to journal › Article › Scientific › peer-review
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In vivo imaging of reactive oxygen and nitrogen species in murine colitis
Asghar, M. N., Emani, R., Alam, C., Helenius, T., Grönroos, T., Sareila, O., U Din, M., Holmdahl, R., Hänninen, A. & Toivola, D., 2014, In: Inflammatory Bowel Diseases. 20, 8, p. 1435–1447Research output: Contribution to journal › Article › Scientific › peer-review
28 Citations (Scopus) -
On the non-linear attachment characteristics of blood to bacterial cellulose/kaolin biomaterials
Soto Véliz, D., Alam, P., Toivola, D., Toivakka, M. & Alam, C., 2014, In: Colloids and Surfaces B: Biointerfaces. 116, p. 176–182 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
17 Citations (Scopus) -
2013
Bacterial cellulose–kaolin nanocomposites for application as biomedical wound healing materials
Wanna, D., Alam, P., Toivola, D. & Alam, C., 2013, In: Advances in Natural Sciences: Nanoscience and Nanotechnology. 4, 4, p. 1–4Research output: Contribution to journal › Article › Scientific › peer-review
45 Citations (Scopus) -
Casein hydrolysate diet controls intestinal T cell activation, free radical production and microbial colonisation in NOD mice
Emani, R., Asghar, M. N., Toivonen, R., Lauren, L., Söderström, M., Toivola, D., Tol EAF, V. & Hänninen, A., 2013, In: Diabetologia. 56, 8, p. 1781–1791 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
18 Citations (Scopus) -
Dramatic Loss of the Chloride Transporter DRA in Mouse Intestinal Epithelia After Keratin 8 Inactivation
Asghar, M., Priyamvada, S., Anbazhagan, A., Silvander, J., Nyström, J., Dudeja, P. & Toivola, D., 2013Research output: Other contribution
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Keratin 8 modulates β-cell stress responses and normoglycaemia
Alam, P., Silvander, J., Daniel, E. N., Tao, G.-Z., Kvarnström, S. M., Alam, C., Bishr Omary, M., Hänninen, A. & Toivola, D., 2013, In: Journal of Cell Science. 126, 24, p. 5635–5644Research output: Contribution to journal › Article › Scientific › peer-review
35 Citations (Scopus) -
2012
Comparative Cellular Toxicity of Hydrophilic and Hydrophobic Microcystins on Caco-2 Cells
PSM, V., Misiorek, J., Spoof, L., Toivola, D. & Meriluoto, J., 2012, In: Toxins. 4, 11, p. 1008–1023 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
79 Citations (Scopus) -
Ex vivo imaging of free radicals reveals robust immune activity in the distal small intestine in NOD mice
Emani, R., Asghar, M. N., Toivonen, R., Lindholm, L., Söderström, M., Tol R, V., Toivola, D. & Hänninen, A., 2012Research output: Other contribution
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Keratin 8-Deletion-Induced Colonic Inflammation and Hyperproliferation are Risk Factors in the Azoxymethane-Induced Colorectal Cancer Model
Misiorek, J., Asghar, M. N., Taimen, P. & Toivola, D., 2012Research output: Other contribution
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Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
Sen Karaman, D., Desai, D., Senthilkumar, Johansson, Råtts, Odén, Eriksson, J., Sahlgren, C., Toivola, D. & Rosenholm, J., 2012, In: Nanoscale Research Letters. 7, 1, p. 1–14Research output: Contribution to journal › Article › Scientific › peer-review
51 Citations (Scopus) -
2011
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
Habtezion, A., Toivola, D., Asghar, M. N., Kronmal, G., Brooks, J., Butcher, E. & Omary, M., 2011, In: Proceedings of the National Academy of Sciences. 108, 4, p. 1445–1450 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
40 Citations (Scopus)