Projects per year
Personal profile
Research interests
My research team at the Structural Bioinformatics Laboratory (SBL) focuses 3D structures of proteins and, particularly, utilizing 3D structures to predict and understand protein function. Our research on the molecular mechanism of infection, inflammation and cancer intertwines crystallography with computational modeling approaches. We aim to find out how proteins interact with other molecules and what is the structural basis for their ligand selectivity. The proteins we are working with are drug targets, off-targets, biomarkers of disease stages, biocatalysts or targets for diagnostics of disease.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Intercepting the Siglec-mediated interactions in cancer and inflammation
01/09/21 → 31/08/23
Project: Academy of Finland/Other Research Councils
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InFLAMES: Innovation Ecosystem based on the Immune System
Takeda, A., Marjamäki, A., Roivainen, A., Hakanen, A., Hänninen, A., Sahlgren, C., Julkunen, I., Ivaska, J., Eriksson, J., Jorma, T., Rinne, J., Knuuti, J., Westermarck, J., Jyrki, H., Gidwani, K., Elima, K., Aires, L., Elo, L. L., Hollmen, M., Johnson, M., Salmi, M., Oresic, M., Poutanen, M., Kortelainen, M., Pentikäinen, O., Raitakari, O., Jaakkola, P., Salminen, P., Taimen, P., Vallittu, P., Rantakari, P., Mattila, P., Nuutila, P., He, Q., Lahesmaa, R., De Figueiredo, R., Jalkanen, S., Lönnberg, T., Soukka, T., Salminen, T. A., Veromaa, T., Lamminmäki, U., Launis, V., Peltola, V., Xiang-Guo, L., Coffey, E., Meinander, A., Toivola, D. & Zhang, H.
01/07/20 → 30/04/23
Project: Academy of Finland/Other Research Councils
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Nordic POP (Patient-Oriented Products)
Rosenholm, J., Zhang, H., Viitala, T., Filppula, A., Salo-Ahen, O., Bobacka, J., Salminen, T. A., Johnson, M., Peltonen, J. & Wang, X.
01/01/18 → 31/12/25
Project: Ministry / Government Agency
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Integrated Structural Biology Infrastructure
01/01/20 → 31/12/21
Project: Academy of Finland/Other Research Councils
Publications
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Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
Sipilä, K., Rognoni, E., Jokinen, J., Tewary, M., Rudan, M. V., Talvi, S., Jokinen, V., Dahlström, K. M., Liakath-Ali, K., Mobasseri, A., Du-Harpur, X., Käpylä, J., Nutt, S. L., Salminen, T. A., Heino, J. & Watt, F. M., 20 Jun 2022, In: Developmental Cell. 57, 12, p. 1453-1465.e7 21 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
Nafamostat is a Potent Human Diamine Oxidase Inhibitor Possibly Augmenting Hypersensitivity Reactions during Nafamostat Administration
Boehm, T., Alix, M., Petroczi, K., Vakal, S., Gludovacz, E., Borth, N., Salminen, T. A. & Jilma, B., 1 Aug 2022, In: Journal of Pharmacology and Experimental Therapeutics. 382, 2, p. 113-122 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
1 Citation (Scopus) -
Conserved lysine residues in decorin binding proteins of Borrelia garinii are critical in adhesion to human brain microvascular endothelial cells
Pietikäinen, A., Åstrand, M., Cuellar, J., Glader, O., Elovaara, H., Rouhiainen, M., Salo, J., Furihata, T., Salminen, T. A. & Hytönen, J., Jun 2021, In: Molecular Microbiology. 115, 6, p. 1395-1409Research output: Contribution to journal › Article › Scientific › peer-review
Open Access2 Citations (Scopus) -
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity
Siddiqui, F. A., Vukic, V., Salminen, T. A. & Abankwa, D., 4 Jun 2021, In: Biomolecules.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical
Gludovacz, E., Schuetzenberger, K., Resch, M., Tillmann, K., Petroczi, K., Schosserer, M., Vondra, S., Vakal, S., Klanert, G., Pollheimer, J., Salminen, T. A., Jilma, B., Borth, N. & Boehm, T., 2021, In: eLife. 10Research output: Contribution to journal › Article › Scientific › peer-review
Open Access5 Citations (Scopus)
Activities
- 3 Hosting an academic visitor
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Wuttinun Raksajit
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Suchanit Ngamkala
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Authen Promariya
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor