Projects per year
Personal profile
Research interests
My research team at the Structural Bioinformatics Laboratory (SBL) focuses 3D structures of proteins and, particularly, utilizing 3D structures to predict and understand protein function. Our research on the molecular mechanism of infection, inflammation and cancer intertwines crystallography with computational modeling approaches. We aim to find out how proteins interact with other molecules and what is the structural basis for their ligand selectivity. The proteins we are working with are drug targets, off-targets, biomarkers of disease stages, biocatalysts or targets for diagnostics of disease.
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Collaborations and top research areas from the last five years
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Nordic Pharmaceutical Translation and Innovation
Rosenholm, J., Viitala, T., Zhang, H., Salo-Ahen, O., Filppula, A., Wang, X., Bansal, K., Kulkov, I., Ameyaw Ahen, F., Salminen, T. A., Airenne, T., Lehtonen, J., Södergård, B. & Rosenberg, S.
01/01/24 → 31/12/28
Project: Research
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Nordic POP (Patient-Oriented Products)
Rosenholm, J., Zhang, H., Viitala, T., Filppula, A., Salo-Ahen, O., Bobacka, J., Salminen, T. A., Johnson, M., Peltonen, J. & Wang, X.
01/01/18 → 31/12/25
Project: Ministry / Government Agency
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Intercepting the Siglec-mediated interactions in cancer and inflammation
01/09/21 → 31/08/23
Project: Research Council of Finland/Other Research Councils
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Integrated Structural Biology Infrastructure
01/01/20 → 31/12/21
Project: Research Council of Finland/Other Research Councils
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Characterization and Homology Modeling of Catalytically Active Recombinant PhaC Ap Protein from Arthrospira platensis.
Duangsri, C., Salminen, T. A., Alix, M., Kaewmongkol, S., Akrimajirachoote, N., Khetkorn, W., Jittapalapong, S., Mäenpää, P., Incharoensakdi, A. & Raksajit, W., 20 May 2023, In: Biology. 12, 5, 15 p., 751.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile27 Downloads (Pure) -
Molecular interactions between human diamine oxidase and heparins
Isaksson, J., Pösö, L., Gludovacz, E., Airenne, T., Jilma, B., Boehm, T. & Salminen, T. A., Jul 2023, 1 p. Springer.Research output: Other contribution
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Proton motive force dissipation drives flavodiiron proteins to the thylakoid membrane for ferredoxin-powered O2photoreduction
Nikkanen, L., Vakal, S., Santana-Sánchez, A., Hubacek, M., Wang, Y., Böhm, M., Gutekunst, K., Salminen, T. A. & Allahverdiyeva, Y., 22 May 2023Research output: Other contribution
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Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis
Jahandideh, A., Virta, J., Li, X-G., Liljenbäck, H., Moisio, O., Ponkamo, J., Rajala, N., Alix, M., Lehtonen, J., Mäyränpää, M. I., Salminen, T. A., Knuuti, J., Jalkanen, S., Saraste, A. & Roivainen, A., 27 Sept 2023, (E-pub ahead of print) In: Journal of Nuclear Cardiology. 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile7 Downloads (Pure) -
Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
Sipilä, K., Rognoni, E., Jokinen, J., Tewary, M., Rudan, M. V., Talvi, S., Jokinen, V., Dahlström, K. M., Liakath-Ali, K., Mobasseri, A., Du-Harpur, X., Käpylä, J., Nutt, S. L., Salminen, T. A., Heino, J. & Watt, F. M., 20 Jun 2022, In: Developmental Cell. 57, 12, p. 1453-1465.e7 21 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure)
Activities
- 3 Hosting an academic visitor
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Wuttinun Raksajit
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Authen Promariya
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Suchanit Ngamkala
Tiina A. Salminen (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor