Projects per year
Personal profile
Research interests
My research team at the Structural Bioinformatics Laboratory (SBL) focuses 3D structures of proteins and, particularly, utilizing 3D structures to predict and understand protein function. Our research on the molecular mechanism of infection, inflammation and cancer intertwines crystallography with computational modeling approaches. We aim to find out how proteins interact with other molecules and what is the structural basis for their ligand selectivity. The proteins we are working with are drug targets, off-targets, biomarkers of disease stages, biocatalysts or targets for diagnostics of disease.
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Intercepting the Siglec-mediated interactions in cancer and inflammation
01/09/21 → 31/08/23
Project: Academy of Finland/Other Research Councils
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InFLAMES: Innovation Ecosystem based on the Immune System
Takeda, A., Marjamäki, A., Roivainen, A., Hakanen, A., Hänninen, A., Sahlgren, C., Julkunen, I., Ivaska, J., Eriksson, J., Jorma, T., Rinne, J., Knuuti, J., Westermarck, J., Jyrki, H., Gidwani, K., Elima, K., Aires, L., Elo, L. L., Hollmen, M., Johnson, M. S., Salmi, M., Oresic, M., Poutanen, M., Kortelainen, M., Pentikäinen, O., Raitakari, O., Jaakkola, P., Salminen, P., Taimen, P., Vallittu, P., Rantakari, P., Mattila, P., Nuutila, P., He, Q., Lahesmaa, R., De Figueiredo, R., Jalkanen, S., Lönnberg, T., Soukka, T., Salminen, T. A., Veromaa, T., Lamminmäki, U., Launis, V., Peltola, V., Xiang-Guo, L., Coffey, E., Meinander, A., Toivola, D. & Zhang, H.
01/07/20 → 30/04/23
Project: Research
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Nordic POP (Patient-Oriented Products)
Rosenholm, J., Zhang, H., Viitala, T., Filppula, A., Salo-Ahen, O., Bobacka, J., Salminen, T. A., Johnson, M. S., Peltonen, J. & Wang, X.
01/01/18 → 31/12/25
Project: Ministry / Government Agency
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Integrated Structural Biology Infrastructure
01/01/20 → 31/12/21
Project: Academy of Finland/Other Research Councils
Publications
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Conserved lysine residues in decorin binding proteins of Borrelia garinii are critical in adhesion to human brain microvascular endothelial cells
Pietikäinen, A., Åstrand, M., Cuellar, J., Glader, O., Elovaara, H., Rouhiainen, M., Salo, J., Furihata, T., Salminen, T. A. & Hytönen, J., Jun 2021, In: Molecular Microbiology. 115, 6Research output: Contribution to journal › Article › Scientific › peer-review
Open Access1 Citation (Scopus) -
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity
Siddiqui, F. A., Vukic, V., Salminen, T. A. & Abankwa, D., 4 Jun 2021, In: Biomolecules.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical
Gludovacz, E., Schuetzenberger, K., Resch, M., Tillmann, K., Petroczi, K., Schosserer, M., Vondra, S., Vakal, S., Klanert, G., Pollheimer, J., Salminen, T. A., Jilma, B., Borth, N. & Boehm, T., 2021, In: eLife. 10Research output: Contribution to journal › Article › Scientific › peer-review
Open Access2 Citations (Scopus) -
Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions
Gludovacz, E., Schuetzenberger, K., Resch, M., Tillmann, K., Petroczi, K., Vondra, S., Vakal, S., Schosserer, M., Virgolini, N., Pollheimer, J., Salminen, T. A., Jilma, B., Borth, N. & Boehm, T., 2021, In: Glycobiology.Research output: Contribution to journal › Article › Scientific › peer-review
1 Citation (Scopus) -
Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling
Siddiqui, F. A., Parkkola, H., Vukic, V., Oetken-Lindholm, C., Jaiswal, A., Kiriazis, A., Pavic, K., Aittokallio, T., Salminen, T. A. & Abankwa, D., 23 Feb 2021, In: Cancers. 13, 4Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)2 Downloads (Pure)