Design considerations for mesoporous silica nanoparticulate systems in facilitating biomedical applications

Diti Desai, Didem Sen Karaman, Neeraj Prabhakar, Sina Tadayon, Alain Duchanoy, Diana Toivola, Sadhana Rajput, Tuomas Näreoja, Jessica Rosenholm

Research output: Contribution to journalArticleScientificpeer-review


Mesoporous silica nanoparticles (MSNs) have advanced to the forefront of multifunctional nanoparticulate systems in nanomedicine, owing to this highly fexible materials platform enabling a multitude of design options, often in a modular fashion. Drug delivery ability, detectability via diferent imaging modalities, and stimuliresponsiveness are often combined into one particle system. Very sophisticated and versatile designs along with impressive demonstrations of applicability have been reported to date, but a common ground when it comes to some critical considerations valid for any nanoparticle intended for biomedical purposes is lacking to some degree. In this study, we attempt to take a glance at some of the most crucial aspects of biomedical nanoparticulate design and relate how they apply specifically toMSNs. These considerations include fuorophore labeling and leaching with respect to immobilization to MSNs, the surrounding conditions, carrier biodegradability, and surface coating. Surface modifcation strategies and surface charge tuning are further considered in conjunction to the relative amount of cellular uptake and serum protein adsorption. Cellular internalization routes and biological techniques used to evaluate especially in vitro biobehavior are discussed. Our attempt is hereby to draw attention to some of the most frequently occurring issues to be considered in the design of MSN systems for biomedical applications.
Original languageUndefined/Unknown
Pages (from-to)16–43
JournalMesoporous Biomaterials
Issue number1
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed


  • Fuorophore labeling
  • Fuorescence properties
  • Photostability
  • Surface coatings
  • Surface charges
  • Cellular internalization routes
  • Serum protein adsorption
  • PEI cytotoxicity

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