Ozonation of carbamazepine and its main transformation products: Product determination and reaction mechanisms

Matilda Kråkström*, Soudabeh Saeid, Pasi Tolvanen, Narendra Kumar, Tapio Salmi, Leif Kronberg, Patrik Eklund

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Carbamazepine (CBZ) is a recalcitrant pharmaceutical often detected in wastewater and in the environment. CBZ can be removed from wastewater through advanced oxidation treatment methods such as ozonation. In this study, CBZ and its transformation product 1-(2-benzaldehyde)-(1H,3H)-quinazoline-2,4-dione (BQD) were ozonated, and the formation and transformation of their ozonation products were investigated using liquid chromatography coupled to ion trap mass spectrometry and high-resolution mass spectrometry as well as nuclear magnetic resonance (NMR). The main products, 1-(2-benzaldehyde)-4-hydro-(1H,3H)-quinazoline-2-one (BQM) and BQD were quantified using isolated standards and LC-UV. Of the original CBZ concentration, 74% was transformed into BQM and 83% of BQM was further transformed into BQD. Both products are more stable than CBZ and could still be detected after 240 min of ozonation. Another major product, 2,2′-azanediyldibenzaldehyde (TP225) was for the first time identified using NMR. Twelve further CBZ products were identified.

OriginalspråkEngelska
Sidor (från-till)23258-23269
Antal sidor12
TidskriftEnvironmental Science and Pollution Research
Volym27
Utgåva18
DOI
StatusPublicerad - 25 apr 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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