Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le, Yong Guo, Jun-Nian Zhou, Jiaqi Yan, Hongbo Zhang, Tan-Phat Huynh*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)
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A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

Original languageEnglish
Pages (from-to)110-116
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - 1 Jan 2022
MoE publication typeA1 Journal article-refereed


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