Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le; Yong Guo; Jun-Nian Zhou; Jiaqi Yan; Hongbo Zhang; Tan-Phat Huynh

doi:10.1016/j.ijbiomac.2021.11.180

Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le, Yong Guo, Jun-Nian Zhou, Jiaqi Yan, Hongbo Zhang, Tan-Phat Huynh^*

^*Corresponding author for this work

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Abstract

A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by ¹H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL ⁻¹ has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

Original language	English
Pages (from-to)	110-116
Journal	International Journal of Biological Macromolecules
Volume	194
DOIs	https://doi.org/10.1016/j.ijbiomac.2021.11.180
Publication status	Published - 1 Jan 2022
MoE publication type	A1 Journal article-refereed

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10.1016/j.ijbiomac.2021.11.180

1-s2.0-S014181302102585X-mainFinal published version, 2.02 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe2023030329307

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and Engineering
Facility/equipment: Facility

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Principal Investigator)
01/09/19 → 31/08/24
Project: Research Council of Finland/Other Research Councils

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title = "Synthesis, characterization and biocompatibility of guar gum-benzoic acid",

abstract = "A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates. ",

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T1 - Synthesis, characterization and biocompatibility of guar gum-benzoic acid

AU - Le, Trung-Anh

AU - Guo, Yong

AU - Zhou, Jun-Nian

AU - Yan, Jiaqi

AU - Zhang, Hongbo

AU - Huynh, Tan-Phat

PY - 2022/1/1

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N2 - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

AB - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

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DO - 10.1016/j.ijbiomac.2021.11.180

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VL - 194

SP - 110

EP - 116

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Synthesis, characterization and biocompatibility of guar gum-benzoic acid

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Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

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