Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le, Yong Guo, Jun-Nian Zhou, Jiaqi Yan, Hongbo Zhang, Tan-Phat Huynh*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

OriginalspråkEngelska
Sidor (från-till)110-116
TidskriftInternational Journal of Biological Macromolecules
Volym194
DOI
StatusPublicerad - 1 jan. 2022
MoE-publikationstypA1 Tidskriftsartikel-refererad

Fingeravtryck

Fördjupa i forskningsämnen för ”Synthesis, characterization and biocompatibility of guar gum-benzoic acid”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här