Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le; Yong Guo; Jun-Nian Zhou; Jiaqi Yan; Hongbo Zhang; Tan-Phat Huynh

doi:10.1016/j.ijbiomac.2021.11.180

Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Trung-Anh Le, Yong Guo, Jun-Nian Zhou, Jiaqi Yan, Hongbo Zhang, Tan-Phat Huynh^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

6 Citeringar (Scopus)

19 Nedladdningar (Pure)

Sammanfattning

A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by ¹H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL ⁻¹ has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

Originalspråk	Engelska
Sidor (från-till)	110-116
Tidskrift	International Journal of Biological Macromolecules
Volym	194
DOI	https://doi.org/10.1016/j.ijbiomac.2021.11.180
Status	Publicerad - 1 jan. 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

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10.1016/j.ijbiomac.2021.11.180

1-s2.0-S014181302102585X-mainSlutlig publicerad version, 2,02 MBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe2023030329307

Åbo Akademi Functional Printing Center
Martti Toivakka (PI), Jessica Rosenholm (PI), Nicklas Anttu (PI), Johan Bobacka (PI), Tan Phat Huynh (PI), Jouko Peltonen (PI), Xiaoju Wang (PI), Carl-Eric Wilen (PI), Chunlin Xu (PI), Hongbo Zhang (PI) & Ronald Österbacka (PI)
Fakulteten för naturvetenskaper och teknik
Utrustning/facilitet: Facilitet

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H.
01/09/19 → 31/08/24
Projekt: FA/Övriga Forskningsråd

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title = "Synthesis, characterization and biocompatibility of guar gum-benzoic acid",

abstract = "A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates. ",

author = "Trung-Anh Le and Yong Guo and Jun-Nian Zhou and Jiaqi Yan and Hongbo Zhang and Tan-Phat Huynh",

year = "2022",

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doi = "10.1016/j.ijbiomac.2021.11.180",

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journal = "International Journal of Biological Macromolecules",

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TY - JOUR

T1 - Synthesis, characterization and biocompatibility of guar gum-benzoic acid

AU - Le, Trung-Anh

AU - Guo, Yong

AU - Zhou, Jun-Nian

AU - Yan, Jiaqi

AU - Zhang, Hongbo

AU - Huynh, Tan-Phat

PY - 2022/1/1

Y1 - 2022/1/1

N2 - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

AB - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL −1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.

U2 - 10.1016/j.ijbiomac.2021.11.180

DO - 10.1016/j.ijbiomac.2021.11.180

M3 - Article

SN - 0141-8130

VL - 194

SP - 110

EP - 116

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Synthesis, characterization and biocompatibility of guar gum-benzoic acid

Sammanfattning

Åtkomst av dokument

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Utrustning

Åbo Akademi Functional Printing Center

Projekt

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Citera det här