JNK Regulation of Depression and Anxiety.

Patrik Hollós, Francesca Marchisella, Eleanor Coffey

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.
OriginalspråkOdefinierat/okänt
Sidor (från-till)145–155
TidskriftBrain Plasticity
Volym3
Utgåva2
DOI
StatusPublicerad - 2018
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

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