JNK Regulation of Depression and Anxiety.

Patrik Hollós, Francesca Marchisella, Eleanor Coffey

Research output: Contribution to journalReview Article or Literature Reviewpeer-review


Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.
Original languageUndefined/Unknown
Pages (from-to)145–155
JournalBrain Plasticity
Issue number2
Publication statusPublished - 2018
MoE publication typeA2 Review article in a scientific journal

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