Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson; Jussi Meriluoto; null Kujari; null Österlund; null Fagerlund; null Hällbom

doi:10.1016/0041-0101(88)90168-7

Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson, Jussi Meriluoto, Kujari, Österlund, Fagerlund, Hällbom

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

80 Sitaatiot (Scopus)

Abstrakti

A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

Alkuperäiskieli	Ei tiedossa
Sivut	161–166
Julkaisu	Toxicon
Vuosikerta	26
Numero	2
DOI - pysyväislinkit	https://doi.org/10.1016/0041-0101(88)90168-7
Tila	Julkaistu - 1988
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1016/0041-0101(88)90168-7

Viittausmuodot

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title = "Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena",

abstract = "A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.",

author = "John Eriksson and Jussi Meriluoto and Kujari and {\"O}sterlund and Fagerlund and H{\"a}llbom",

year = "1988",

doi = "10.1016/0041-0101(88)90168-7",

language = "Odefinierat/ok{\"a}nt",

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TY - JOUR

T1 - Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

AU - Eriksson, John

AU - Meriluoto, Jussi

AU - Kujari, null

AU - Österlund, null

AU - Fagerlund, null

AU - Hällbom, null

PY - 1988

Y1 - 1988

N2 - A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

AB - A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

U2 - 10.1016/0041-0101(88)90168-7

DO - 10.1016/0041-0101(88)90168-7

M3 - Artikel

SN - 0041-0101

VL - 26

SP - 161

EP - 166

JO - Toxicon

JF - Toxicon

IS - 2

ER -