Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson, Jussi Meriluoto, Kujari, Österlund, Fagerlund, Hällbom

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    Sammanfattning

    A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)161–166
    TidskriftToxicon
    Volym26
    Utgåva2
    DOI
    StatusPublicerad - 1988
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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