Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson; Jussi Meriluoto; null Kujari; null Österlund; null Fagerlund; null Hällbom

doi:10.1016/0041-0101(88)90168-7

Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson, Jussi Meriluoto, Kujari, Österlund, Fagerlund, Hällbom

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Abstract

A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

Original language	Undefined/Unknown
Pages (from-to)	161–166
Journal	Toxicon
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/0041-0101(88)90168-7
Publication status	Published - 1988
MoE publication type	A1 Journal article-refereed

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10.1016/0041-0101(88)90168-7

Cite this

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title = "Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena",

abstract = "A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.",

author = "John Eriksson and Jussi Meriluoto and Kujari and {\"O}sterlund and Fagerlund and H{\"a}llbom",

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T1 - Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

AU - Eriksson, John

AU - Meriluoto, Jussi

AU - Kujari, null

AU - Österlund, null

AU - Fagerlund, null

AU - Hällbom, null

PY - 1988

Y1 - 1988

N2 - A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

AB - A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

U2 - 10.1016/0041-0101(88)90168-7

DO - 10.1016/0041-0101(88)90168-7

M3 - Artikel

SN - 0041-0101

VL - 26

SP - 161

EP - 166

JO - Toxicon

JF - Toxicon

IS - 2

ER -