Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

John Eriksson, Jussi Meriluoto, Kujari, Österlund, Fagerlund, Hällbom

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    Abstract

    A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.
    Original languageUndefined/Unknown
    Pages (from-to)161–166
    JournalToxicon
    Volume26
    Issue number2
    DOIs
    Publication statusPublished - 1988
    MoE publication typeA1 Journal article-refereed

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