Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

JJ Virta; S Aalto; T Järvenpaa; Mira Karrasch; J Kaprio; M Koskenvuo; I Räihä; T Viljanen; JO Rinne

doi:10.1136/jnnp.2008.145466

Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

JJ Virta, S Aalto, T Järvenpaa, Mira Karrasch, J Kaprio, M Koskenvuo, I Räihä, T Viljanen, JO Rinne

Research output: Contribution to journal › Article › Scientific › peer-review

12 Citations (Scopus)

Abstract

Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.

Original language	Undefined/Unknown
Pages (from-to)	259–266
Number of pages	8
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	80
Issue number	3
DOIs	https://doi.org/10.1136/jnnp.2008.145466
Publication status	Published - 2009
MoE publication type	A1 Journal article-refereed

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10.1136/jnnp.2008.145466

Cite this

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title = "Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease",

abstract = "Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.",

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T1 - Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

AU - Virta, JJ

AU - Aalto, S

AU - Järvenpaa, T

AU - Karrasch, Mira

AU - Kaprio, J

AU - Koskenvuo, M

AU - Räihä, I

AU - Viljanen, T

AU - Rinne, JO

PY - 2009

Y1 - 2009

N2 - Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.

AB - Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.

U2 - 10.1136/jnnp.2008.145466

DO - 10.1136/jnnp.2008.145466

M3 - Artikel

SN - 0022-3050

VL - 80

SP - 259

EP - 266

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 3

ER -