Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

JJ Virta, S Aalto, T Järvenpaa, Mira Karrasch, J Kaprio, M Koskenvuo, I Räihä, T Viljanen, JO Rinne

    Research output: Contribution to journalArticleScientificpeer-review

    10 Citations (Scopus)

    Abstract

    Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.
    Original languageUndefined/Unknown
    Pages (from-to)259–266
    Number of pages8
    JournalJournal of Neurology, Neurosurgery and Psychiatry
    Volume80
    Issue number3
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

    Cite this