Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

JJ Virta, S Aalto, T Järvenpaa, Mira Karrasch, J Kaprio, M Koskenvuo, I Räihä, T Viljanen, JO Rinne

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    10 Sitaatiot (Scopus)

    Abstrakti

    Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.
    AlkuperäiskieliEi tiedossa
    Sivut259–266
    Sivumäärä8
    JulkaisuJournal of Neurology, Neurosurgery and Psychiatry
    Vuosikerta80
    Numero3
    DOI - pysyväislinkit
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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