Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

JJ Virta, S Aalto, T Järvenpaa, Mira Karrasch, J Kaprio, M Koskenvuo, I Räihä, T Viljanen, JO Rinne

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    10 Citeringar (Scopus)

    Sammanfattning

    Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)259–266
    Antal sidor8
    TidskriftJournal of Neurology, Neurosurgery and Psychiatry
    Volym80
    Utgåva3
    DOI
    StatusPublicerad - 2009
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Citera det här