Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Dmitry Murzin, Teemu Heikkilä

    Research output: Contribution to journalArticleScientificpeer-review

    6 Citations (Scopus)

    Abstract

    Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior
    Original languageUndefined/Unknown
    Pages (from-to)579–592
    JournalChemical Engineering Communications
    Volume201
    Issue number5
    DOIs
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed

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