Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Dmitry Murzin; Teemu Heikkilä

doi:10.1080/00986445.2013.782290

Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Dmitry Murzin, Teemu Heikkilä

Research output: Contribution to journal › Article › Scientific › peer-review

13 Citations (Scopus)

Abstract

Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior

Original language	Undefined/Unknown
Pages (from-to)	579–592
Journal	Chemical Engineering Communications
Volume	201
Issue number	5
DOIs	https://doi.org/10.1080/00986445.2013.782290
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

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10.1080/00986445.2013.782290

Cite this

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title = "Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica",

abstract = "Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior",

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AB - Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior

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