Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Dmitry Murzin, Teemu Heikkilä

    Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

    7 Sitaatiot (Scopus)

    Abstrakti

    Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior
    AlkuperäiskieliEi tiedossa
    Sivut579–592
    JulkaisuChemical Engineering Communications
    Vuosikerta201
    Numero5
    DOI - pysyväislinkit
    TilaJulkaistu - 2014
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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