Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Dmitry Murzin, Teemu Heikkilä

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    7 Citeringar (Scopus)

    Sammanfattning

    Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)579–592
    TidskriftChemical Engineering Communications
    Volym201
    Utgåva5
    DOI
    StatusPublicerad - 2014
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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