Sammanfattning
Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treat-ing dissolution data with sigmoid behavior
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 579–592 |
Tidskrift | Chemical Engineering Communications |
Volym | 201 |
Nummer | 5 |
DOI | |
Status | Publicerad - 2014 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |