Isomerization of bicyclic terpene epoxides into allylic alcohols without changing of the initial structure

Yulia Demidova, OV Ardashov, OA Simakova, Olga Simakova, KP Volcho, NF Salakhutdinov, Dmitry Murzin

    Research output: Contribution to journalArticleScientificpeer-review

    41 Citations (Scopus)

    Abstract

    A novel method of (1S,2R,3R,5R)-6,6-dimethy1-4-methylenebicyclo[3.1.1]heptane-2,3-diol synthesis, which is a valuable intermediate in the synthesis of a perspective potent anti-Parkinson drugs, in the presence of TiO2 was proposed. Catalytic activity of TiO2 in the bicyclic terpene epoxides isomerization to corresponding allylic alcohols without changing of the initial structure was demonstrated, contrary to titania-supported Au catalysts which promoted rearrangement with predominant formation of a cyclopentene alpha-hydroxy ketone.
    Original languageUndefined/Unknown
    Pages (from-to)162–166
    JournalJournal of Molecular Catalysis A: Chemical
    Volume388-389
    DOIs
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed

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