Isomerization of bicyclic terpene epoxides into allylic alcohols without changing of the initial structure

Yulia Demidova, OV Ardashov, OA Simakova, Olga Simakova, KP Volcho, NF Salakhutdinov, Dmitry Murzin

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    40 Citeringar (Scopus)

    Sammanfattning

    A novel method of (1S,2R,3R,5R)-6,6-dimethy1-4-methylenebicyclo[3.1.1]heptane-2,3-diol synthesis, which is a valuable intermediate in the synthesis of a perspective potent anti-Parkinson drugs, in the presence of TiO2 was proposed. Catalytic activity of TiO2 in the bicyclic terpene epoxides isomerization to corresponding allylic alcohols without changing of the initial structure was demonstrated, contrary to titania-supported Au catalysts which promoted rearrangement with predominant formation of a cyclopentene alpha-hydroxy ketone.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)162–166
    TidskriftJournal of Molecular Catalysis A: Chemical
    Volym388-389
    DOI
    StatusPublicerad - 2014
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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