Vimentin at the core of wound healing

Leila S. Coelho-Rato, Sepideh Parvanian, Mayank Kumar Modi, John E. Eriksson*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review


As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial–mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell survival, and stress resilience. Here, we explore the role of vimentin at each phase of wound healing, with focus on how it integrates different signaling pathways and protects cells in the fluctuating and challenging environments that characterize a healing tissue.
Sidor (från-till)239-254
Antal sidor16
TidskriftTrends in Cell Biology
StatusPublicerad - mars 2024
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift


  • intermediate filaments
  • EMT
  • tissue repair
  • wound healing
  • vimentin


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