Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

FS Ekholm; IM Mandity; F Fulop; Reko Leino

doi:10.1016/j.tetlet.2010.12.109

Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

FS Ekholm, IM Mandity, F Fulop, Reko Leino

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

15 Citeringar (Scopus)

Sammanfattning

A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.

Originalspråk	Odefinierat/okänt
Sidor (från-till)	1839–1841
Antal sidor	3
Tidskrift	Tetrahedron Letters
Volym	52
Nummer	16
DOI	https://doi.org/10.1016/j.tetlet.2010.12.109
Status	Publicerad - 2011
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Nyckelord

Benzyl/benzylidene
Flow chemistry
Heterogenous catalysis
Protective groups

Åtkomst av dokument

10.1016/j.tetlet.2010.12.109

Citera det här

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title = "Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry",

abstract = "A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.",

keywords = "Benzyl/benzylidene, Flow chemistry, Heterogenous catalysis, Protective groups, Benzyl/benzylidene, Flow chemistry, Heterogenous catalysis, Protective groups, Benzyl/benzylidene, Flow chemistry, Heterogenous catalysis, Protective groups",

author = "FS Ekholm and IM Mandity and F Fulop and Reko Leino",

year = "2011",

doi = "10.1016/j.tetlet.2010.12.109",

language = "Odefinierat/ok{\"a}nt",

volume = "52",

pages = "1839–1841",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

AU - Ekholm, FS

AU - Mandity, IM

AU - Fulop, F

AU - Leino, Reko

PY - 2011

Y1 - 2011

N2 - A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.

AB - A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.

KW - Benzyl/benzylidene

KW - Flow chemistry

KW - Heterogenous catalysis

KW - Protective groups

KW - Benzyl/benzylidene

KW - Flow chemistry

KW - Heterogenous catalysis

KW - Protective groups

KW - Benzyl/benzylidene

KW - Flow chemistry

KW - Heterogenous catalysis

KW - Protective groups

U2 - 10.1016/j.tetlet.2010.12.109

DO - 10.1016/j.tetlet.2010.12.109

M3 - Artikel

SN - 0040-4039

VL - 52

SP - 1839

EP - 1841

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -