Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

Martina Stekrova; Narendra Kumar; Päivi Mäki-Arvela; Atte Aho; Johan Linden; Konstantin P. Volcho; Nariman F. Salakhutdinov; Dmitry Yu Murzin

doi:10.1007/s11144-013-0615-9

Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

Martina Stekrova, Narendra Kumar, Päivi Mäki-Arvela, Atte Aho, Johan Linden, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu Murzin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO₂ to Al2O₃ ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

Original language	English
Pages (from-to)	449-458
Number of pages	10
Journal	Reaction Kinetics, Mechanisms and Catalysis
Volume	110
Issue number	2
DOIs	https://doi.org/10.1007/s11144-013-0615-9
Publication status	Published - Aug 2013
MoE publication type	A1 Journal article-refereed

Keywords

Isomerization
Mesoporous material
Verbenol oxide
Zeolite

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10.1007/s11144-013-0615-9

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title = "Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts",

abstract = "High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Br{\o}nsted and Lewis acid sites.",

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author = "Martina Stekrova and Narendra Kumar and P{\"a}ivi M{\"a}ki-Arvela and Atte Aho and Johan Linden and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.} and Murzin, {Dmitry Yu}",

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doi = "10.1007/s11144-013-0615-9",

language = "English",

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T1 - Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

AU - Stekrova, Martina

AU - Kumar, Narendra

AU - Mäki-Arvela, Päivi

AU - Aho, Atte

AU - Linden, Johan

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

AU - Murzin, Dmitry Yu

PY - 2013/8

Y1 - 2013/8

N2 - High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

AB - High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

KW - Isomerization

KW - Mesoporous material

KW - Verbenol oxide

KW - Zeolite

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U2 - 10.1007/s11144-013-0615-9

DO - 10.1007/s11144-013-0615-9

M3 - Article

AN - SCOPUS:84893707379

SN - 1878-5190

VL - 110

SP - 449

EP - 458

JO - Reaction Kinetics, Mechanisms and Catalysis

JF - Reaction Kinetics, Mechanisms and Catalysis

IS - 2

ER -

Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

Abstract

Keywords

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