Opening of monoterpene epoxide to a potent anti- Parkinson compound of para-menthane structure over heterogeneous catalysts

Martina Stekrova, Narendra Kumar, Päivi Mäki-Arvela, Atte Aho, Johan Linden, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu Murzin*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

Original languageEnglish
Pages (from-to)449-458
Number of pages10
JournalReaction Kinetics, Mechanisms and Catalysis
Volume110
Issue number2
DOIs
Publication statusPublished - Dec 2013
MoE publication typeA1 Journal article-refereed

Keywords

  • Isomerization
  • Mesoporous material
  • Verbenol oxide
  • Zeolite

Fingerprint Dive into the research topics of 'Opening of monoterpene epoxide to a potent anti- Parkinson compound of para-menthane structure over heterogeneous catalysts'. Together they form a unique fingerprint.

Cite this