One-pot synthesis of (R)-2-acetoxy-1-indanone from 1,2-indanedione combining metal catalyzed hydrogenation and chemoenzymatic dynamic kinetic resolution

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Abstract

Combination of the regioselective hydrogenation of the prochiral diketone 1,2-indanedione with chemoenzymatic dynamic kinetic resolution of the resulting rac-2-hydroxy-1-indanone was investigated. A new simple to operate, one-pot reaction sequence provides the valuable building block (R)-2-acetoxy-1-indanone in moderate enantiopurity (86-92% ee) and a competitive isolated yield (39%) compared with a traditional isolated batch reaction approach.
Original languageUndefined/Unknown
Pages (from-to)150–160
Number of pages11
JournalCatalysis Science and Technology
Volume5
Issue number1
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

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