Sammanfattning
Combination of the regioselective hydrogenation of the prochiral diketone 1,2-indanedione with chemoenzymatic dynamic kinetic resolution of the resulting rac-2-hydroxy-1-indanone was investigated. A new simple to operate, one-pot reaction sequence provides the valuable building block (R)-2-acetoxy-1-indanone in moderate enantiopurity (86-92% ee) and a competitive isolated yield (39%) compared with a traditional isolated batch reaction approach.
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 150–160 |
Antal sidor | 11 |
Tidskrift | Catalysis Science and Technology |
Volym | 5 |
Nummer | 1 |
DOI | |
Status | Publicerad - 2015 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |