One-pot chemo-biocatalytic synthesis of R-1-phenylethyl acetate from acetophenone hydrogenation over Pd/Al2O3 catalyst

Päivi Mäki-Arvela, Serap Sahin, Narendra Kumar, Teemu Heikkilä, Vesa Pekka Lehto, Tapio Salmi, Dmitry Yu Murzin*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

The kinetics in the one-pot synthesis of R-1-phenyl ethylacetate starting from acetophenone have been systematically investigated by using different amounts of hydrogenation catalyst and an immobilized enzyme simultaneously. The kinetic results revealed that there is interference between their catalytic performance indicating that these catalysts were not acting independently but in concert. The reaction mechanism was very complex, since besides the consecutive reactions, hydrogen-acylation, also dehydration of an intermediate product, (R,S)-1-phenylethanol occurred leading to styrene and its instantaneous hydrogenation to ethyl benzene. This work presents the kinetic regularities, quantitative understanding of which remains a challenge.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalApplied Catalysis A: General
Volume350
Issue number1
DOIs
Publication statusPublished - 15 Nov 2008
MoE publication typeA1 Journal article-refereed

Keywords

  • Acetophenone
  • Acylation
  • Chemo-biocatalysis
  • Hydrogenation
  • R-1-phenyl ethylacetate

Fingerprint Dive into the research topics of 'One-pot chemo-biocatalytic synthesis of R-1-phenylethyl acetate from acetophenone hydrogenation over Pd/Al<sub>2</sub>O<sub>3</sub> catalyst'. Together they form a unique fingerprint.

Cite this