One-pot chemo-biocatalytic synthesis of R-1-phenylethyl acetate from acetophenone hydrogenation over Pd/Al2O3 catalyst

Päivi Mäki-Arvela, Serap Sahin, Narendra Kumar, Teemu Heikkilä, Vesa Pekka Lehto, Tapio Salmi, Dmitry Yu Murzin*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

8 Citeringar (Scopus)

Sammanfattning

The kinetics in the one-pot synthesis of R-1-phenyl ethylacetate starting from acetophenone have been systematically investigated by using different amounts of hydrogenation catalyst and an immobilized enzyme simultaneously. The kinetic results revealed that there is interference between their catalytic performance indicating that these catalysts were not acting independently but in concert. The reaction mechanism was very complex, since besides the consecutive reactions, hydrogen-acylation, also dehydration of an intermediate product, (R,S)-1-phenylethanol occurred leading to styrene and its instantaneous hydrogenation to ethyl benzene. This work presents the kinetic regularities, quantitative understanding of which remains a challenge.

OriginalspråkEngelska
Sidor (från-till)24-29
Antal sidor6
TidskriftApplied Catalysis A: General
Volym350
Utgåva1
DOI
StatusPublicerad - 15 nov 2008
MoE-publikationstypA1 Tidskriftsartikel-refererad

Fingeravtryck Fördjupa i forskningsämnen för ”One-pot chemo-biocatalytic synthesis of R-1-phenylethyl acetate from acetophenone hydrogenation over Pd/Al<sub>2</sub>O<sub>3</sub> catalyst”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här