Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

Ari Hietanen; Tiina Saloranta; Reko Leino; Liisa T. Kanerva

doi:10.1016/j.tetasy.2012.09.003

Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

Ari Hietanen, Tiina Saloranta, Reko Leino, Liisa T. Kanerva

Research output: Contribution to journal › Article › Scientific › peer-review

11 Citations (Scopus)

Abstract

The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	1629–1632
Number of pages	4
Journal	Tetrahedron: Asymmetry
Volume	23
Issue number	24
DOIs	https://doi.org/10.1016/j.tetasy.2012.09.003
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

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10.1016/j.tetasy.2012.09.003

Cite this

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title = "Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers",

abstract = "The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.",

author = "Ari Hietanen and Tiina Saloranta and Reko Leino and Kanerva, {Liisa T.}",

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journal = "Tetrahedron: Asymmetry",

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T1 - Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

AU - Hietanen, Ari

AU - Saloranta, Tiina

AU - Leino, Reko

AU - Kanerva, Liisa T.

PY - 2012

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N2 - The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.

AB - The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetasy.2012.09.003

DO - 10.1016/j.tetasy.2012.09.003

M3 - Artikel

SN - 0957-4166

VL - 23

SP - 1629

EP - 1632

JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

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