Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

Ari Hietanen, Tiina Saloranta, Reko Leino, Liisa T. Kanerva

    Research output: Contribution to journalArticleScientificpeer-review

    9 Citations (Scopus)

    Abstract

    The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.
    Original languageUndefined/Unknown
    Pages (from-to)1629–1632
    Number of pages4
    JournalTetrahedron: Asymmetry
    Volume23
    Issue number24
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

    Cite this