Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

Ari Hietanen, Tiina Saloranta, Reko Leino, Liisa T. Kanerva

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    9 Citeringar (Scopus)

    Sammanfattning

    The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)1629–1632
    Antal sidor4
    TidskriftTetrahedron: Asymmetry
    Volym23
    Utgåva24
    DOI
    StatusPublicerad - 2012
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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