Sammanfattning
The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy (1H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)) was also performed in a subset of subjects during clamp. In dataset A, 48 participants were studied during fasting with brain 1H-MRS, while in dataset B 21 participants underwent paired brain 1H-MRS acquisitions under fasting and clamp conditions. In dataset C 16 subjects underwent brain 18F-FDG-PET and 1H-MRS during clamp. In the fasting state, total N-acetylaspartate was lower in subjects with obesity, while brain myo-inositol increased in response to hyperinsulinemia similarly in both lean participants and subjects with obesity. During clamp, BGU correlated positively with brain glutamine/glutamate, total choline, and total creatine levels. Following weight loss, brain creatine levels were increased, whereas increases in other metabolites remained not significant. To conclude, insulin signaling and glucose metabolism are significantly coupled with several of the changes in brain metabolites that occur in obesity.
Originalspråk | Engelska |
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Sidor (från-till) | 407-418 |
Tidskrift | Journal of Cerebral Blood Flow and Metabolism |
Volym | 44 |
Nummer | 3 |
DOI | |
Status | Publicerad - mars 2024 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |
Finansiering
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by the European Foundation for the Study of Diabetes (EFSD) (PN). ER reports funding from the Emil Aaltonen Foundation, the Finnish Cultural Foundation, the Paulo Foundation, the Maud Kuistilan Muistosäätiö, the Finnish Diabetes Foundation, the Finnish Medical Foundation, and from the Paavo Nurmi Foundation. LN reports funding from Sigrid Juselius Stiftelse and Academy of Finland (294897, 332225). Acknowledgements
Finansiärer | Finansiärsnummer |
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Finnish Diabetes Foundation | |
Sigrid Juselius Stiftelse and Academy of Finland | 294897, 332225 |
Finnish Medical Foundation | |
Maud Kuistila Memorial Foundation | |
European Foundation for the Study of Diabetes | |
Finska Kulturfonden | |
Emil Aaltosen Säätiö | |
Paulo Foundation | |
Paavo Nurmen Säätiö |
Nyckelord
- PET imaging