'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights

MB Omary, Ku NO, GZ Tao, Diana Toivola, J Liao

Tutkimustuotos: LehtiartikkeliArtikkelivertaisarvioitu

225 Sitaatiot (Scopus)

Abstrakti

Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are among the most abundant cellular phosphoproteins; their phosphorylation typically involves multiple sites at repeat or unique motifs, preferentially within the 'head' or 'tail' domains. Phosphorylation and dephosphorylation are essential for the regulation of IF dynamics by modulating the intrinsic properties of IFs: solubility, conformation and filament organization, and, in addition, for the regulation of other IF post-translational modifications. These phosphorylation-regulated properties dictate generalized and context-dependent IF functions that reflect their tissue-specific expression. Most important among IF phosphorylation-mediated functions are the regulation of IF cellular or subcellular compartmentalization, levels and turnover, binding with associated proteins, susceptibility to cell stresses (including apoptosis), tissue-specific functions and IF-associated disease pathogenesis (where IF hyperphosphorylation also serves as a tissue-injury marker).
AlkuperäiskieliEi tiedossa
Sivut383–394
Sivumäärä12
JulkaisuTrends in Biochemical Sciences
Vuosikerta31
Numero7
DOI - pysyväislinkit
TilaJulkaistu - 2006
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Viittausmuodot