Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition

Carolina Mendez Galvez; Matthias Böhme; Reko Leino; Risto Savela

doi:10.1002/ejoc.202000046

Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition

Carolina Mendez Galvez, Matthias Böhme, Reko Leino, Risto Savela

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Abstract

Transition metal‐catalyzed [2+2+2] cyclotrimerization is a powerful method to synthesize substituted benzene derivatives with optimal atom efficiency. However, controlling regio‐ and chemoselectivity is difficult. We present a cobalt catalyzed cycloaddition of alkynes, which provides the cycloaddition products in high yields and excellent regioselectivity in the presence of a pyridine‐2,6‐diimine ligand.

Original language	English
Pages (from-to)	1708–1719
Journal	European Journal of Organic Chemistry
Issue number	11
DOIs	https://doi.org/10.1002/ejoc.202000046
Publication status	Published - 22 Mar 2020
MoE publication type	A1 Journal article-refereed

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abstract = "Transition metal‐catalyzed [2+2+2] cyclotrimerization is a powerful method to synthesize substituted benzene derivatives with optimal atom efficiency. However, controlling regio‐ and chemoselectivity is difficult. We present a cobalt catalyzed cycloaddition of alkynes, which provides the cycloaddition products in high yields and excellent regioselectivity in the presence of a pyridine‐2,6‐diimine ligand. ",

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AU - Mendez Galvez, Carolina

AU - Böhme, Matthias

AU - Leino, Reko

AU - Savela, Risto

N1 - iok

PY - 2020/3/22

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N2 - Transition metal‐catalyzed [2+2+2] cyclotrimerization is a powerful method to synthesize substituted benzene derivatives with optimal atom efficiency. However, controlling regio‐ and chemoselectivity is difficult. We present a cobalt catalyzed cycloaddition of alkynes, which provides the cycloaddition products in high yields and excellent regioselectivity in the presence of a pyridine‐2,6‐diimine ligand.

AB - Transition metal‐catalyzed [2+2+2] cyclotrimerization is a powerful method to synthesize substituted benzene derivatives with optimal atom efficiency. However, controlling regio‐ and chemoselectivity is difficult. We present a cobalt catalyzed cycloaddition of alkynes, which provides the cycloaddition products in high yields and excellent regioselectivity in the presence of a pyridine‐2,6‐diimine ligand.

U2 - 10.1002/ejoc.202000046

DO - 10.1002/ejoc.202000046

M3 - Article

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EP - 1719

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 11

ER -

Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition

Abstract

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