Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition

Carolina Mendez Galvez, Matthias Böhme, Reko Leino, Risto Savela

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)


Transition metal‐catalyzed [2+2+2] cyclotrimerization is a powerful method to synthesize substituted benzene derivatives with optimal atom efficiency. However, controlling regio‐ and chemoselectivity is difficult. We present a cobalt catalyzed cycloaddition of alkynes, which provides the cycloaddition products in high yields and excellent regioselectivity in the presence of a pyridine‐2,6‐diimine ligand.

Original languageEnglish
Pages (from-to)1708–1719
JournalEuropean Journal of Organic Chemistry
Issue number11
Publication statusPublished - 22 Mar 2020
MoE publication typeA1 Journal article-refereed


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