Recent advances towards mass spectrometry-based clinical lipidomics

Samira Salihovic, Santosh Lamichane, Tuulia Hyötyläinen, Matej Orešič*

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

3 Citations (Scopus)
11 Downloads (Pure)

Abstract

The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices. The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest innovations in microsampling techniques have the potential to make a substantial contribution to clinical lipidomics. The review also shows that more work is needed to harmonize results across diverse lipidomics platforms and avoid significant errors in analysis and reporting. The increased implementation of internal standards and standard reference materials in analytical workflows will aid in this direction.

Original languageEnglish
Article number102370
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume76
DOIs
Publication statusPublished - Oct 2023
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Biomarkers
  • Human health
  • Lipidomics
  • Mass spectrometry
  • Microsampling

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