TY - JOUR
T1 - Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight
AU - Pekkarinen, Laura
AU - Kantonen, Tatu
AU - Oikonen, Vesa
AU - Haaparanta-Solin, Merja
AU - Aarnio, Richard
AU - Dickens, Alex M
AU - von Eyken, Annie
AU - Latva-Rasku, Aino
AU - Dadson, Prince
AU - Kirjavainen, Anna K
AU - Rajander, Johan
AU - Kalliokoski, Kari
AU - Rönnemaa, Tapani
AU - Nummenmaa, Lauri
AU - Nuutila, Pirjo
N1 - © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023/7
Y1 - 2023/7
N2 - OBJECTIVE: Cannabinoid type 1 receptors (CB1R) modulate feeding behavior and energy homeostasis, and the CB1R tone is dysgulated in obesity. This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men.METHODS: Healthy males with high (HR, n = 16) or low (LR, n = 20) obesity risk were studied with fluoride 18-labeled FMPEP-d2 positron emission tomography to quantify CB1R availability in abdominal adipose tissue, brown adipose tissue, muscle, and brain. Obesity risk was assessed by BMI, physical exercise habits, and familial obesity risk, including parental overweight, obesity, and type 2 diabetes. To assess insulin sensitivity, fluoro-[18 F]-deoxy-2-D-glucose positron emission tomography during hyperinsulinemic-euglycemic clamp was performed. Serum endocannabinoids were analyzed.RESULTS: CB1R availability in abdominal adipose tissue was lower in the HR than in the LR group, whereas no difference was found in other tissues. CB1R availability of abdominal adipose tissue and brain correlated positively with insulin sensitivity and negatively with unfavorable lipid profile, BMI, body adiposity, and inflammatory markers. Serum arachidonoyl glycerol concentration was associated with lower CB1R availability of the whole brain, unfavorable lipid profile, and higher serum inflammatory markers.CONCLUSIONS: The results suggest endocannabinoid dysregulation already in the preobesity state.
AB - OBJECTIVE: Cannabinoid type 1 receptors (CB1R) modulate feeding behavior and energy homeostasis, and the CB1R tone is dysgulated in obesity. This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men.METHODS: Healthy males with high (HR, n = 16) or low (LR, n = 20) obesity risk were studied with fluoride 18-labeled FMPEP-d2 positron emission tomography to quantify CB1R availability in abdominal adipose tissue, brown adipose tissue, muscle, and brain. Obesity risk was assessed by BMI, physical exercise habits, and familial obesity risk, including parental overweight, obesity, and type 2 diabetes. To assess insulin sensitivity, fluoro-[18 F]-deoxy-2-D-glucose positron emission tomography during hyperinsulinemic-euglycemic clamp was performed. Serum endocannabinoids were analyzed.RESULTS: CB1R availability in abdominal adipose tissue was lower in the HR than in the LR group, whereas no difference was found in other tissues. CB1R availability of abdominal adipose tissue and brain correlated positively with insulin sensitivity and negatively with unfavorable lipid profile, BMI, body adiposity, and inflammatory markers. Serum arachidonoyl glycerol concentration was associated with lower CB1R availability of the whole brain, unfavorable lipid profile, and higher serum inflammatory markers.CONCLUSIONS: The results suggest endocannabinoid dysregulation already in the preobesity state.
KW - Male
KW - Humans
KW - Overweight
KW - Insulin Resistance/physiology
KW - Diabetes Mellitus, Type 2
KW - Receptors, Cannabinoid
KW - Obesity
KW - Abdominal Fat/diagnostic imaging
KW - Endocannabinoids
KW - Cannabinoids
KW - Adipose Tissue
KW - PET imaging
U2 - 10.1002/oby.23770
DO - 10.1002/oby.23770
M3 - Article
C2 - 37368516
SN - 1930-7381
VL - 31
SP - 1844
EP - 1858
JO - Obesity
JF - Obesity
IS - 7
ER -