Infant gut microbiota and negative and fear reactivity

Venla Huovinen; Anna-Katariina Aatsinki; Eeva-Leena Kataja; Eveliina Munukka; Anniina Keskitalo; Santosh Lamichhane; Peppi Raunioniemi; David J Bridgett; Leo Lahti; Siobhain M O'Mahony; Alex Dickens; Riikka Korja; Hasse Karlsson; Saara Nolvi; Linnea Karlsson

doi:10.1017/S0954579423001396

Infant gut microbiota and negative and fear reactivity

Venla Huovinen, Anna-Katariina Aatsinki, Eeva-Leena Kataja, Eveliina Munukka, Anniina Keskitalo, Santosh Lamichhane, Peppi Raunioniemi, David J Bridgett, Leo Lahti, Siobhain M O'Mahony, Alex Dickens, Riikka Korja, Hasse Karlsson, Saara Nolvi, Linnea Karlsson

Turku Bioscience

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Abstract

BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.

METHODS: Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child's age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child's age of 12 months (n = 276).

CONCLUSIONS: We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies.

Original language	English
Number of pages	16
Journal	Development and Psychopathology
DOIs	https://doi.org/10.1017/S0954579423001396
Publication status	E-pub ahead of print - 17 Nov 2023
MoE publication type	A1 Journal article-refereed

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10.1017/S0954579423001396

infant-gut-microbiota-and-negative-and-fear-reactivityFinal published version, 0.99 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe202402167478

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Huovinen, V., Aatsinki, A.-K., Kataja, E.-L., Munukka, E., Keskitalo, A., Lamichhane, S., Raunioniemi, P., Bridgett, D. J., Lahti, L., O'Mahony, S. M., Dickens, A., Korja, R., Karlsson, H., Nolvi, S., & Karlsson, L. (2023). Infant gut microbiota and negative and fear reactivity. Development and Psychopathology. Advance online publication. https://doi.org/10.1017/S0954579423001396

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title = "Infant gut microbiota and negative and fear reactivity",

abstract = "BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.METHODS: Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child's age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child's age of 12 months (n = 276).CONCLUSIONS: We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies.",

keywords = "alpha diversity, negative reactivity, genus abundance, fear reactivity, beta diversity",

author = "Venla Huovinen and Anna-Katariina Aatsinki and Eeva-Leena Kataja and Eveliina Munukka and Anniina Keskitalo and Santosh Lamichhane and Peppi Raunioniemi and Bridgett, {David J} and Leo Lahti and O'Mahony, {Siobhain M} and Alex Dickens and Riikka Korja and Hasse Karlsson and Saara Nolvi and Linnea Karlsson",

year = "2023",

month = nov,

day = "17",

doi = "10.1017/S0954579423001396",

language = "English",

journal = "Development and Psychopathology",

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T1 - Infant gut microbiota and negative and fear reactivity

AU - Huovinen, Venla

AU - Aatsinki, Anna-Katariina

AU - Kataja, Eeva-Leena

AU - Munukka, Eveliina

AU - Keskitalo, Anniina

AU - Lamichhane, Santosh

AU - Raunioniemi, Peppi

AU - Bridgett, David J

AU - Lahti, Leo

AU - O'Mahony, Siobhain M

AU - Dickens, Alex

AU - Korja, Riikka

AU - Karlsson, Hasse

AU - Nolvi, Saara

AU - Karlsson, Linnea

PY - 2023/11/17

Y1 - 2023/11/17

N2 - BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.METHODS: Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child's age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child's age of 12 months (n = 276).CONCLUSIONS: We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies.

AB - BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.METHODS: Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child's age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child's age of 12 months (n = 276).CONCLUSIONS: We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies.

KW - alpha diversity

KW - negative reactivity

KW - genus abundance

KW - fear reactivity

KW - beta diversity

U2 - 10.1017/S0954579423001396

DO - 10.1017/S0954579423001396

M3 - Article

C2 - 37974473

SN - 0954-5794

JO - Development and Psychopathology

JF - Development and Psychopathology

ER -

Infant gut microbiota and negative and fear reactivity

Abstract

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