Impact of substituting K2O for Na2O on physico-chemical properties and in vitro bioactivity of bioactive glass S53P4

Polina Sinitsyna; Markus Engblom; Leena Hupa

doi:10.1016/j.oceram.2023.100440

Impact of substituting K₂O for Na₂O on physico-chemical properties and in vitro bioactivity of bioactive glass S53P4

Polina Sinitsyna^*, Markus Engblom, Leena Hupa^*

^*Corresponding author for this work

Laboratory of Molecular Science and Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The impact of substituting K₂O for Na₂O (0–100%) on the physico-chemical and bioactive properties of bioactive glass S53P4 was studied. The thermal properties were evaluated using differential thermal analysis and high-temperature microscopy. Ion release kinetics was measured in static and dynamic TRIS-buffer and SBF using inductively coupled plasma optical emission spectroscopy. Substituting K₂O for Na₂O showed a mixed-alkali effect (MAE) for the thermal properties with a minimum value for the glass containing around 20% K₂O. The hot-working range increased with the potassium content. The glass with 66% of Na₂O replaced with K₂O exhibited MAE in static TRIS by giving the biggest pH change and ion release at 24 h. The same glass showed the lowest pH and Si species release in dynamic SBF at the longest dissolution time, 72 h. Both single-alkali glasses showed higher in vitro bioactivity in dynamic SBF. The results provide tools for tailoring new bioactive glass compositions with desired properties.

Original language	English
Article number	100440
Journal	Open Ceramics
Volume	16
DOIs	https://doi.org/10.1016/j.oceram.2023.100440
Publication status	Published - Dec 2023
MoE publication type	A1 Journal article-refereed

Keywords

Bioactive glass S53P4
Dynamic dissolution
Ion release
Mixed-alkali effect
Static dissolution

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10.1016/j.oceram.2023.100440Licence: CC BY-NC-ND

1-s2.0-S2666539523001128-mainFinal published version, 9.16 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe20231130150381

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title = "Impact of substituting K2O for Na2O on physico-chemical properties and in vitro bioactivity of bioactive glass S53P4",

abstract = "The impact of substituting K2O for Na2O (0–100%) on the physico-chemical and bioactive properties of bioactive glass S53P4 was studied. The thermal properties were evaluated using differential thermal analysis and high-temperature microscopy. Ion release kinetics was measured in static and dynamic TRIS-buffer and SBF using inductively coupled plasma optical emission spectroscopy. Substituting K2O for Na2O showed a mixed-alkali effect (MAE) for the thermal properties with a minimum value for the glass containing around 20% K2O. The hot-working range increased with the potassium content. The glass with 66% of Na2O replaced with K2O exhibited MAE in static TRIS by giving the biggest pH change and ion release at 24 h. The same glass showed the lowest pH and Si species release in dynamic SBF at the longest dissolution time, 72 h. Both single-alkali glasses showed higher in vitro bioactivity in dynamic SBF. The results provide tools for tailoring new bioactive glass compositions with desired properties.",

keywords = "Bioactive glass S53P4, Dynamic dissolution, Ion release, Mixed-alkali effect, Static dissolution",

author = "Polina Sinitsyna and Markus Engblom and Leena Hupa",

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year = "2023",

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doi = "10.1016/j.oceram.2023.100440",

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volume = "16",

journal = "Open Ceramics",

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T1 - Impact of substituting K2O for Na2O on physico-chemical properties and in vitro bioactivity of bioactive glass S53P4

AU - Sinitsyna, Polina

AU - Engblom, Markus

AU - Hupa, Leena

PY - 2023/12

Y1 - 2023/12

N2 - The impact of substituting K2O for Na2O (0–100%) on the physico-chemical and bioactive properties of bioactive glass S53P4 was studied. The thermal properties were evaluated using differential thermal analysis and high-temperature microscopy. Ion release kinetics was measured in static and dynamic TRIS-buffer and SBF using inductively coupled plasma optical emission spectroscopy. Substituting K2O for Na2O showed a mixed-alkali effect (MAE) for the thermal properties with a minimum value for the glass containing around 20% K2O. The hot-working range increased with the potassium content. The glass with 66% of Na2O replaced with K2O exhibited MAE in static TRIS by giving the biggest pH change and ion release at 24 h. The same glass showed the lowest pH and Si species release in dynamic SBF at the longest dissolution time, 72 h. Both single-alkali glasses showed higher in vitro bioactivity in dynamic SBF. The results provide tools for tailoring new bioactive glass compositions with desired properties.

AB - The impact of substituting K2O for Na2O (0–100%) on the physico-chemical and bioactive properties of bioactive glass S53P4 was studied. The thermal properties were evaluated using differential thermal analysis and high-temperature microscopy. Ion release kinetics was measured in static and dynamic TRIS-buffer and SBF using inductively coupled plasma optical emission spectroscopy. Substituting K2O for Na2O showed a mixed-alkali effect (MAE) for the thermal properties with a minimum value for the glass containing around 20% K2O. The hot-working range increased with the potassium content. The glass with 66% of Na2O replaced with K2O exhibited MAE in static TRIS by giving the biggest pH change and ion release at 24 h. The same glass showed the lowest pH and Si species release in dynamic SBF at the longest dissolution time, 72 h. Both single-alkali glasses showed higher in vitro bioactivity in dynamic SBF. The results provide tools for tailoring new bioactive glass compositions with desired properties.

KW - Bioactive glass S53P4

KW - Dynamic dissolution

KW - Ion release

KW - Mixed-alkali effect

KW - Static dissolution

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VL - 16

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JF - Open Ceramics

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ER -

Impact of substituting K₂O for Na₂O on physico-chemical properties and in vitro bioactivity of bioactive glass S53P4

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Keywords

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