Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina; Eleonora Macchia; Angelo Tricase; Cecilia Scandurra; Anna Imbriano; Fabrizio Torricelli; Nicola Cioffi; Luisa Torsi; Paolo Bollella

doi:10.1002/elsa.202100216

Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina, Eleonora Macchia, Angelo Tricase, Cecilia Scandurra, Anna Imbriano, Fabrizio Torricelli, Nicola Cioffi, Luisa Torsi^*, Paolo Bollella^*

^*Corresponding author for this work

Physics

Research output: Contribution to journal › Short survey › peer-review

9 Citations (Scopus)

27 Downloads (Pure)

Abstract

The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

Original language	English
Article number	e2100216
Journal	Electrochemical Science Advances
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/elsa.202100216
Publication status	Published - Jun 2023
MoE publication type	O2 Other

Keywords

enzymes
extended gate configuration
field-effect transistors
modified electrodes
potentiometric sensors

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10.1002/elsa.202100216Licence: CC BY

Electrochemical Science Adv - 2022 - Sarcina - Enzyme based field effect transistor State‐of‐the‐art and futureFinal published version, 2.22 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202401314929

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title = "Enzyme based field effect transistor: State-of-the-art and future perspectives",

abstract = "The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices{\textquoteright} configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.",

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author = "Lucia Sarcina and Eleonora Macchia and Angelo Tricase and Cecilia Scandurra and Anna Imbriano and Fabrizio Torricelli and Nicola Cioffi and Luisa Torsi and Paolo Bollella",

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doi = "10.1002/elsa.202100216",

language = "English",

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T2 - State-of-the-art and future perspectives

AU - Sarcina, Lucia

AU - Macchia, Eleonora

AU - Tricase, Angelo

AU - Scandurra, Cecilia

AU - Imbriano, Anna

AU - Torricelli, Fabrizio

AU - Cioffi, Nicola

AU - Torsi, Luisa

AU - Bollella, Paolo

PY - 2023/6

Y1 - 2023/6

N2 - The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

AB - The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

KW - enzymes

KW - extended gate configuration

KW - field-effect transistors

KW - modified electrodes

KW - potentiometric sensors

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JO - Electrochemical Science Advances

JF - Electrochemical Science Advances

IS - 3

M1 - e2100216

ER -

Enzyme based field effect transistor: State-of-the-art and future perspectives

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Keywords

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