Dysregulation of Microbiota in Patients With First-Episode Psychosis Is Associated With Symptom Severity and Treatment Response

Partho Sen, Emese Prandovszky, Jarno K Honkanen, Ou Chen, Robert Yolken, Jaana Suvisaari

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Background: The gut microbiome has been implicated in the pathogenesis of mental disorders where the gut-brain axis acts as a bidirectional communication network. Methods: Herein, we investigated the compositional and functional differences of gut microbiome between patients with first-episode psychosis (FEP) (n = 26) and healthy control participants (n = 22) using whole-genome shotgun sequencing. In addition, we assessed the oral microbiome in patients with FEP (n = 13) and listed their taxonomic diversity. Results: Our findings suggest that there is a dysbiosis of gut microbiota in patients with FEP. Relative abundance of Bifidobacterium adolescentis, Prevotella copri, and Turicibacter sanguinis was markedly increased (linear discriminant analysis scores [log 10] > 1, and Mann-Whitney U test; false discovery rate–adjusted p values < .05) in the FEP group compared with the healthy control participants. Pathway analysis indicated that several metabolic pathways, particularly deoxyribonucleotide biosynthesis, branched-chain amino acid biosynthesis, tricarboxylic acid cycle, and fatty acid elongation and biosynthesis, were dysregulated in the FEP group compared with the healthy control group. In addition, this preliminary study was able to identify specific gut microbes (at baseline) that were predictive of weight gain in the FEP group at a 1-year follow-up. Bacteroides dorei, Bifidobacterium adolescentis, Turicibacter sanguinis, Roseburia spp., and Ruminococcus lactaris were positively associated (eXtreme gradient boosting, XGBoost regression model, Shapley additive explanations, R 2 = 0.82) with weight gain. Conclusions: Our findings may suggest the involvement of gut microbiota in the pathogenesis of psychosis. The benefit of modulation of the gut microbiome in the treatment of psychotic disorders should be explored further.

Original languageEnglish
Pages (from-to)370-379
Number of pages10
JournalBiological Psychiatry
Volume95
Issue number4
DOIs
Publication statusPublished - 15 Feb 2024
MoE publication typeA1 Journal article-refereed

Keywords

  • Humans
  • Firmicutes
  • Microbiota
  • Psychotic Disorders
  • Weight Gain

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