Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Kalle T Rytkönen; Nigatu Adossa; Mehrad Mahmoudian; Tapio Lönnberg; Matti Poutanen; Laura L Elo

doi:10.1530/REP-22-0079

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Kalle T Rytkönen, Nigatu Adossa, Mehrad Mahmoudian, Tapio Lönnberg, Matti Poutanen, Laura L Elo

Turku Bioscience

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Abstract

IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.

ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

Original language	English
Pages (from-to)	V9-V13
Number of pages	5
Journal	Reproduction
Volume	164
Issue number	5
DOIs	https://doi.org/10.1530/REP-22-0079
Publication status	Published - 1 Nov 2022
MoE publication type	A1 Journal article-refereed

Keywords

Decidua/metabolism
Female
Humans
Killer Cells, Natural/metabolism
Pre-Eclampsia/metabolism
Pregnancy
Stromal Cells
Uterus

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10.1530/REP-22-0079

rep-REP-22-0079Final published version, 2.59 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202403019374

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title = "Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia",

abstract = "IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.",

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doi = "10.1530/REP-22-0079",

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T1 - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

AU - Rytkönen, Kalle T

AU - Adossa, Nigatu

AU - Mahmoudian, Mehrad

AU - Lönnberg, Tapio

AU - Poutanen, Matti

AU - Elo, Laura L

PY - 2022/11/1

Y1 - 2022/11/1

N2 - IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

AB - IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

KW - Decidua/metabolism

KW - Female

KW - Humans

KW - Killer Cells, Natural/metabolism

KW - Pre-Eclampsia/metabolism

KW - Pregnancy

KW - Stromal Cells

KW - Uterus

U2 - 10.1530/REP-22-0079

DO - 10.1530/REP-22-0079

M3 - Article

C2 - 36111648

SN - 1470-1626

VL - 164

SP - V9-V13

JO - Reproduction

JF - Reproduction

IS - 5

ER -

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Abstract

Keywords

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