Abstract
IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.
ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.
Original language | English |
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Pages (from-to) | V9-V13 |
Number of pages | 5 |
Journal | Reproduction |
Volume | 164 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Nov 2022 |
MoE publication type | A1 Journal article-refereed |
Keywords
- Decidua/metabolism
- Female
- Humans
- Killer Cells, Natural/metabolism
- Pre-Eclampsia/metabolism
- Pregnancy
- Stromal Cells
- Uterus