Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

Taru Garthwaite, Tanja Sjöros, Saara Laine, Mikko Koivumäki, Henri Vähä-Ypyä, Olli Eskola, Johan Rajander, Petri Kallio, Maria Saarenhovi, Eliisa Löyttyniemi, Harri Sievänen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

OBJECTIVE: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).

METHODS: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.

RESULTS: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.

CONCLUSION: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.

Original languageEnglish
Number of pages6
JournalScandinavian Journal of Medicine and Science in Sports
DOIs
Publication statusE-pub ahead of print - 14 Dec 2022
MoE publication typeA1 Journal article-refereed

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