Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

Taru Garthwaite; Tanja Sjöros; Saara Laine; Mikko Koivumäki; Henri Vähä-Ypyä; Olli Eskola; Johan Rajander; Petri Kallio; Maria Saarenhovi; Eliisa Löyttyniemi; Harri Sievänen; Noora Houttu; Kirsi Laitinen; Kari Kalliokoski; Tommi Vasankari; Juhani Knuuti; Ilkka Heinonen

doi:10.1111/sms.14287

Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

Taru Garthwaite, Tanja Sjöros, Saara Laine, Mikko Koivumäki, Henri Vähä-Ypyä, Olli Eskola, Johan Rajander, Petri Kallio, Maria Saarenhovi, Eliisa Löyttyniemi, Harri Sievänen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen

Turku PET Centre

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

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Abstract

OBJECTIVE: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).

METHODS: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.

RESULTS: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.

CONCLUSION: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.

Original language	English
Number of pages	6
Journal	Scandinavian Journal of Medicine and Science in Sports
DOIs	https://doi.org/10.1111/sms.14287
Publication status	E-pub ahead of print - 14 Dec 2022
MoE publication type	A1 Journal article-refereed

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10.1111/sms.14287

Scandinavian Med Sci Sports - 2022 - Garthwaite - Associations of sedentary time physical activity and fitness withFinal published version, 223 KBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202301316615

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Garthwaite, T., Sjöros, T., Laine, S., Koivumäki, M., Vähä-Ypyä, H., Eskola, O., Rajander, J., Kallio, P., Saarenhovi, M., Löyttyniemi, E., Sievänen, H., Houttu, N., Laitinen, K., Kalliokoski, K., Vasankari, T., Knuuti, J., & Heinonen, I. (2022). Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome. Scandinavian Journal of Medicine and Science in Sports. Advance online publication. https://doi.org/10.1111/sms.14287

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title = "Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome",

abstract = "OBJECTIVE: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).METHODS: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.RESULTS: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.CONCLUSION: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.",

author = "Taru Garthwaite and Tanja Sj{\"o}ros and Saara Laine and Mikko Koivum{\"a}ki and Henri V{\"a}h{\"a}-Ypy{\"a} and Olli Eskola and Johan Rajander and Petri Kallio and Maria Saarenhovi and Eliisa L{\"o}yttyniemi and Harri Siev{\"a}nen and Noora Houttu and Kirsi Laitinen and Kari Kalliokoski and Tommi Vasankari and Juhani Knuuti and Ilkka Heinonen",

note = "{\textcopyright} 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.",

year = "2022",

month = dec,

day = "14",

doi = "10.1111/sms.14287",

language = "English",

journal = "Scandinavian Journal of Medicine and Science in Sports",

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publisher = "John Wiley and Sons",

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Garthwaite, T, Sjöros, T, Laine, S, Koivumäki, M, Vähä-Ypyä, H, Eskola, O, Rajander, J, Kallio, P, Saarenhovi, M, Löyttyniemi, E, Sievänen, H, Houttu, N, Laitinen, K, Kalliokoski, K, Vasankari, T, Knuuti, J & Heinonen, I 2022, 'Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome', Scandinavian Journal of Medicine and Science in Sports. https://doi.org/10.1111/sms.14287

TY - JOUR

T1 - Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

AU - Garthwaite, Taru

AU - Sjöros, Tanja

AU - Laine, Saara

AU - Koivumäki, Mikko

AU - Vähä-Ypyä, Henri

AU - Eskola, Olli

AU - Rajander, Johan

AU - Kallio, Petri

AU - Saarenhovi, Maria

AU - Löyttyniemi, Eliisa

AU - Sievänen, Harri

AU - Houttu, Noora

AU - Laitinen, Kirsi

AU - Kalliokoski, Kari

AU - Vasankari, Tommi

AU - Knuuti, Juhani

AU - Heinonen, Ilkka

PY - 2022/12/14

Y1 - 2022/12/14

N2 - OBJECTIVE: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).METHODS: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.RESULTS: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.CONCLUSION: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.

AB - OBJECTIVE: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).METHODS: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.RESULTS: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.CONCLUSION: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.

U2 - 10.1111/sms.14287

DO - 10.1111/sms.14287

M3 - Article

C2 - 36517882

SN - 0905-7188

JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

ER -

Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

Abstract

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