TY - JOUR
T1 - 3D printed drug delivery devices: perspectives and technical challenges
AU - Palo, Mirja
AU - Holländer, Jenny
AU - Suominen, Jaakko
AU - Yliruusi, J
AU - Sandler, Niklas
PY - 2017
Y1 - 2017
N2 - Introduction: The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems.Areas covered: In this review, an overview is provided on the relevant accomplishments in the development of 3D printed drug delivery systems, as well as the technical challenges surrounding the 3D printing of personalized drug-loaded medical devices and dosage forms. Furthermore, observations are presented on the future perspectives of pharmaceutical 3D printing.Expert commentary: The 3D printing has enabled the fabrication of prototypes of DDD with varying complexity and shows that customization of drug products is possible. There is potential to improve patient-specific drug therapies of the future using printing technologies. The technological advancements, new scientific concepts, interdisciplinary work and defined regulatory guidelines will continue to support and strengthen the prospects of 3D printing as an option in the manufacture of medical products.
AB - Introduction: The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems.Areas covered: In this review, an overview is provided on the relevant accomplishments in the development of 3D printed drug delivery systems, as well as the technical challenges surrounding the 3D printing of personalized drug-loaded medical devices and dosage forms. Furthermore, observations are presented on the future perspectives of pharmaceutical 3D printing.Expert commentary: The 3D printing has enabled the fabrication of prototypes of DDD with varying complexity and shows that customization of drug products is possible. There is potential to improve patient-specific drug therapies of the future using printing technologies. The technological advancements, new scientific concepts, interdisciplinary work and defined regulatory guidelines will continue to support and strengthen the prospects of 3D printing as an option in the manufacture of medical products.
KW - Personalized medicine
KW - oral drug delivery
KW - Fused deposition modelling
KW - Three-dimensional printing
KW - Solid freeform fabrication
KW - Tailored dosage forms
KW - Personalized medicine
KW - oral drug delivery
KW - Fused deposition modelling
KW - Three-dimensional printing
KW - Solid freeform fabrication
KW - Tailored dosage forms
KW - Personalized medicine
KW - oral drug delivery
KW - Fused deposition modelling
KW - Three-dimensional printing
KW - Solid freeform fabrication
KW - Tailored dosage forms
U2 - 10.1080/17434440.2017.1363647
DO - 10.1080/17434440.2017.1363647
M3 - Översiktsartikel
SN - 1743-4440
VL - 14
SP - 685
EP - 696
JO - Expert Review of Medical Devices
JF - Expert Review of Medical Devices
IS - 9
ER -