Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

Essi Laajala, Ubaid Ullah Kalim, Toni Grönroos, Omid Rasool, Viivi Halla-aho, Mikko Konki, Roosa Kattelus, Juha Mykkänen, Mirja Nurmio, Mari Vähä-Mäkilä, Henna Kallionpää, Niina Lietzén, Bishwa R. Ghimire, Asta Laiho, Heikki Hyöty, Laura L. Elo, Jorma Ilonen, Mikael Knip, Riikka J. Lund, Matej OrešičRiitta Veijola, Harri Lähdesmäki, Jorma Toppari, Riitta Lahesmaa*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2 Nedladdningar (Pure)


Aims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Methods: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. Results: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05. Conclusions/interpretation: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset. Graphical abstract: [Figure not available: see fulltext.]

Sidor (från-till)1534-1540
Antal sidor7
StatusPublicerad - sep. 2022
MoE-publikationstypA1 Tidskriftsartikel-refererad


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