TY - JOUR
T1 - Ultra-sensitive protein detection with organic electrochemical transistors printed on plastic substrates
AU - Macchia, Eleonora
AU - Romele, Paolo
AU - Manoli, Kyriaki
AU - Ghittorelli, Matteo
AU - Magliulo, Maria
AU - M Kovács-Vajna, Zsolt
AU - Torricelli, Fabrizio
AU - Torsi, Luisa
PY - 2018
Y1 - 2018
N2 - The detection of protein biomarkers is of great importance in the early diagnosis of severe pathological states. Although in the last decade many approaches to achieve ultra-sensitive protein detection have been developed, most of them require complicated assay set-ups, hindering their adoption in point-of-care applications and on-spot diagnosis. Here we show an organic electrochemical transistor (OECT) biosensor printed on plastic substrates that can selectively detect Immunoglobulin G (IgG) with an unprecedented attomolar detection limit. The OECT is used as a transducer of the biorecognition event taking place at the gate electrode. The measured concentrations are well below the detectable limits of the leading clinical diagnostic enzyme-linked immunosorbent assay, and comparable to the ones gathered with the label-needing single molecule arrays platform. Our work benchmarks the role of plastic OECT-based biosensors as a powerful tool in simple, low cost, yet non-invasive, ultra-sensitive, and widely applicable immunoassay technology.
AB - The detection of protein biomarkers is of great importance in the early diagnosis of severe pathological states. Although in the last decade many approaches to achieve ultra-sensitive protein detection have been developed, most of them require complicated assay set-ups, hindering their adoption in point-of-care applications and on-spot diagnosis. Here we show an organic electrochemical transistor (OECT) biosensor printed on plastic substrates that can selectively detect Immunoglobulin G (IgG) with an unprecedented attomolar detection limit. The OECT is used as a transducer of the biorecognition event taking place at the gate electrode. The measured concentrations are well below the detectable limits of the leading clinical diagnostic enzyme-linked immunosorbent assay, and comparable to the ones gathered with the label-needing single molecule arrays platform. Our work benchmarks the role of plastic OECT-based biosensors as a powerful tool in simple, low cost, yet non-invasive, ultra-sensitive, and widely applicable immunoassay technology.
U2 - 10.1088/2058-8585/aad0cb
DO - 10.1088/2058-8585/aad0cb
M3 - Article
SN - 2058-8585
SP - –
JO - Flexible and Printed Electronics
JF - Flexible and Printed Electronics
ER -