Sammanfattning
products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing
purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without
addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 × 2 mm). X-ray powder
diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent
on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug
loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period
of 7 days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis
indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the
potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release.
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 1099–1107 |
Tidskrift | Journal of Pharmaceutical Sciences |
Volym | 104 |
Nummer | 3 |
DOI | |
Status | Publicerad - 2015 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |
Nyckelord
- biomaterials
- extrusion
- polymeric drug delivery system
- poly(lactic/glycolic) acid (PLGA or PLA)
- controlled release
- Anti-infectives
- spectroscopy
- polymers
- microscopy
- Drug delivery systems