The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

Sepideh Parvanian; Leila S. Coelho-Rato; John E. Eriksson; Alison E. Patteson

doi:10.1016/j.ceb.2023.102233

The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

Sepideh Parvanian
, Leila S. Coelho-Rato
, John E. Eriksson
, Alison E. Patteson^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

12 Citeringar (Scopus)

77 Nedladdningar (Pure)

Sammanfattning

Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.

Originalspråk	Engelska
Artikelnummer	102233
Antal sidor	8
Tidskrift	Current Opinion in Cell Biology
Volym	85
DOI	https://doi.org/10.1016/j.ceb.2023.102233
Status	Publicerad - dec. 2023
MoE-publikationstyp	A2 Översiktsartikel artikel i en vetenskaplig tidskrift

Finansiering

This work was supported by Academy of Finland , Sigrid Jusélius Foundation , Magnus Ehrnrooth Foundation , the Endowment of the Åbo Akademi University , K. Albin Johanssons stiftelse , Maud Kuistila Memorial Foundation , Liv och Hälsa Foundation , Otto A Malm Foundation , Finnish Cultural Foundation , Swedish Cultural Foundation , Ella and Georg Ehrnrooth Foundation and the Foundation “Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse” . This work was also supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM142963 and National Science Foundation award number MCB 2026747 granted to AP. We thank Solveig Eriksson for the help with the graphical design. Graphics were created with BioRender.com .

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10.1016/j.ceb.2023.102233

Parvanian et alAccepterat manuskript från författare, 813 KBLicens: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe2024120198220

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abstract = "Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.",

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AU - Coelho-Rato, Leila S.

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AU - Patteson, Alison E.

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AB - Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.

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The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

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