The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations

Keyphrases

• Receptor Conformation 100%
• In the Wild 33%
• Human Malignancies 33%
• Structure-based Rational Design 33%
• Targeted Treatment 33%
• ErbB4 33%
• Normal Activity 33%
• Transmembrane Signaling 33%
• Structural Units 33%
• Kinase mutation 33%
• Comprehensive Characterization 33%
• Structural Motion 33%
• Active State 33%
• Epidermal Growth Factor Receptor Protein 33%
• Cell Mobility 33%
• Activating mutation 33%
• Organ Development 33%
• ERBB2 Protein 33%
• Lung Cancer 33%
• Ionic Interaction 33%
• ERBB Genes 33%
• ErbB3 33%
• Kinase Activity 33%

Biochemistry, Genetics and Molecular Biology

• ERBB3 26%
• Receptor Tyrosine Kinase 26%
• Induced Mutation 26%
• Organogenesis 26%
• Gene Mutation 26%
• ERBB4 26%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Tyrosine Kinase 26%
• Homodimer 26%