The cytoskeleton of digestive epithelia in health and disease

Ku NO, XJ Zhou, Diana Toivola, MB Omary

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

170 Citeringar (Scopus)

Sammanfattning

The mammalian cell cytoskeleton consists of a diverse group of fibrillar elements that play a pivotal role in mediating a number of digestive and nondigestive cell functions, including secretion, absorption, motility, mechanical integrity, and mitosis. The cytoskeleton of higher-eukaryotic cells consists of three highly abundant major protein families: microfilaments (MF), microtubules (MT), and intermediate filaments (IF), as well as a growing number of associated proteins. Within digestive epithelia, the prototype members of these three protein families are actins, tubulins, and keratins, respectively. This review highlights the important structural, regulatory, functional, and unique features of the three major cytoskeletal protein groups in digestive epithelia. The emerging exciting biological aspects of these protein groups are their involvement in cell signaling via direct or indirect interaction with a growing list of associated proteins (MF, MT, IF), the identification of several disease-causing mutations (IF, MF), the functional role that they play in protection from environmental stresses (IF), and their functional integration via several linker proteins that bridge two or potentially ail three of these groups together. The use of agents that target specific cytoskeletal elements as therapeutic modalities for digestive diseases offers potential unique areas of intervention that remain to be fully explored.
OriginalspråkOdefinierat/okänt
Sidor (från-till)G1108–G1137
Antal sidor30
TidskriftAJP - Gastrointestinal and Liver Physiology
Volym277
Utgåva6
DOI
StatusPublicerad - 1999
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Nyckelord

  • microfilaments
  • microtubules
  • tubulin
  • intermediate filaments
  • keratins

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