Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems

Jessica Rosenholm; Emilia Peuhu; John Eriksson; Cecilia Sahlgren; Lindén

doi:10.1021/nl901589y

Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems

Jessica Rosenholm, Emilia Peuhu, John Eriksson, Cecilia Sahlgren, Lindén

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

214 Citeringar (Scopus)

Sammanfattning

Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.

Originalspråk	Odefinierat/okänt
Sidor (från-till)	3308–3311
Tidskrift	Nano Letters
Volym	9
Nummer	9
DOI	https://doi.org/10.1021/nl901589y
Status	Publicerad - 2009
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

The financial support from the Academy of Finland Grants 128477 (E.P.) and 131034 (C.S.), the European Union (NanoEar project) (J.M.R.) and the partial financial support from the Tor, Joe, and Pentti Borg foundation are gratefully acknowledged.

Åtkomst av dokument

10.1021/nl901589y

Citera det här

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abstract = "Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.",

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AU - Lindén, null

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AB - Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.

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