Synthesis of Divalent 2,2 '-Linked Mannose Derivatives by Homodimerization

FS Ekholm, M Polakova, AJ Pawlowicz, Reko Leino

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    25 Citeringar (Scopus)

    Sammanfattning

    Several studies have implicated (1 -> 2)-linked mannans as biologically relevant compounds. Recently, there has been a growing interest in the synthesis of multivalent carbohydrate assemblies due to their ability to target multiple receptors simultaneously. In the present work, a protective group strategy, based oil the methodology originally developed by Crich, has been utilized for the homodimerization of olefinic carbohydrates, allowing a highly diastereoselective synthesis of some divalent structures. Furthermore, it is shown that divalent donors tray undergo coupling reactions without losses ill stereoselectivity or efficiency, The strategies described may potentially be applied to the synthesis of diverse neoglycoconjugates and of oligosaccharides.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)567–576
    Antal sidor10
    TidskriftSYNTHESIS
    Nummer4
    DOI
    StatusPublicerad - 2009
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Nyckelord

    • (1 -> 2)-linked mannans
    • carbohydrates
    • diastereoselective synthesis
    • divalent molecules
    • homodimerization

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