Synthesis, characterisation and theoretical calculations of 2,6-diaminopurine etheno derivatives

P Virta, A Koch, MU Roslund, Peter Mattjus, E Kleinpeter, Leif Kronberg, Rainer Sjöholm, KD Klika

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    40 Citeringar (Scopus)

    Sammanfattning

    Four derivatives of 2,6-diaminopurine (1) were synthesised and characterised. When 1 was reacted with chloroacetaldehyde, 5-aminoimidazo[2,1- i] purine (2), 9-aminoimidazo[2,1-b]purine (3), 9-aminoimidazo[1,2- a]purine (4) and diimidazo[2,1-b: 2', 1'-i]purine (5) were formed. The purified products (3 - 5) were fully characterised by MS, complete NMR assignments as well as fluorescence and UV spectroscopy. The purified, isolated yields of these products ( 3 - 5) varied from 2.5 to 30%. The relative stability of different tautomers was investigated by theoretical calculations. Fluorescence characteristics are also discussed and compared to the starting material 1 and a reference molecule 2-aminopurine.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)2924–2929
    Antal sidor6
    TidskriftOrganic and Biomolecular Chemistry
    Volym3
    Utgåva16
    DOI
    StatusPublicerad - 2005
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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