Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

Cheng-Bin Yim, Kirsi Mikkola, Veronica Fagerholm, Viki-Veikko Elomaa, Tamiko Ishizu, Johan Rajander, Joern Schlesinger, Anne Roivainen, Pirjo Nuutila, Olof Solin

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    14 Citeringar (Scopus)

    Sammanfattning

    Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)1006–1012
    Antal sidor7
    TidskriftNuclear Medicine and Biology
    Volym40
    Utgåva8
    DOI
    StatusPublicerad - 2013
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Nyckelord

    • Copper-64
    • Exendin
    • GLP-1 receptor
    • NODAGA
    • Renal brush border membrane

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